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Scandinavian Journal of Gastroenterology Volume 22, 1987 - Issue 6
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Original Article

Secretory State and Acute Gastric Mucosal Injury in Sepsis

S. Arvidsson Dept. of Surgery and Dept. of Pathology, Malmo General Hospital, University of Lund, Malmö, Sweden
,
K. Fält Dept. of Surgery and Dept. of Pathology, Malmo General Hospital, University of Lund, Malmö, Sweden
&
U. Haglund Dept. of Surgery and Dept. of Pathology, Malmo General Hospital, University of Lund, Malmö, Sweden
Pages 763-768 | Received 01 Dec 1986, Accepted 22 Feb 1987, Published online: 08 Jul 2009
 
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Abstract

Arvidsson S, Fäit K, Haglund U. Secretory state and acute gastric mucosal injury in sepsis. Scand J Gastroenterol 1987, 22, 763-768

Cats were subjected to a standardized 3-h septicemia by intravenous infusion of live Escherichia coli in an LD50 dose. The effect of pentagastrin stimulation on the development of gastric mucosal injury was studied. There was no hemodynamic difference between the series during septicemia. Thus, pentagastrin did not induce increased gastric blood flow during the period of E. coli infusion. Intraluminal gastric pH was lower in the series given pentagastrin during the last 2h of septicemia. Nevertheless, the extent of gastric mucosal injury was similar in the two groups, whereas the depth of injury was, if anything, less pronounced in the pentagastrin-stimulated group.

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