Influence of Vasoactive Intestinal Peptide, Secretin, and Ala⁴, Val⁵-Secretin on the Net Movements of Electrolytes, Fluid, and Mucus in the Rat Colon in Vivo

U. M. Farack Medizinische Klinik Innenstadt, University of Munich, Munich, FRG; Max-Planck-Institut für Biochemie, Martinsried/Munich, FRG

J. Reiter Medizinische Klinik Innenstadt, University of Munich, Munich, FRG; Max-Planck-Institut für Biochemie, Martinsried/Munich, FRG

M. Gross Medizinische Klinik Innenstadt, University of Munich, Munich, FRG; Max-Planck-Institut für Biochemie, Martinsried/Munich, FRG

L. Moroder Medizinische Klinik Innenstadt, University of Munich, Munich, FRG; Max-Planck-Institut für Biochemie, Martinsried/Munich, FRG

E. Wünsch Medizinische Klinik Innenstadt, University of Munich, Munich, FRG; Max-Planck-Institut für Biochemie, Martinsried/Munich, FRG

K. Loeschke Medizinische Klinik Innenstadt, University of Munich, Munich, FRG; Max-Planck-Institut für Biochemie, Martinsried/Munich, FRG

Abstract

The effect of vasoactive intestinal peptide (VIP), secretin, and VIP-secretin (Ala⁴, Val⁵-secretin) on the net movements of sodium, potassium, fluid, and mucus was investigated in the rat colon perfused in vivo. Peptides (1-100 μg/kg ± h) were infused intra-arterially. VIP influenced electrolyte and fluid movements at a threshold dose 10- to 100-fold lower than secretin, whereas the secretory efficacy was not significantly different. Replacing the NH₂-terminal hexapeptide of secretin by that of VIP did not markedly alter the effect of secretin. Mucus output was stimulated weakly by all three peptides. The results indicate that the larger colonic secretory activity of VIP as compared to secretin is not primarily due to the difference in their NH₂-terminal sequence but probably requires the intact molecule.

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Influence of Vasoactive Intestinal Peptide, Secretin, and Ala⁴, Val⁵-Secretin on the Net Movements of Electrolytes, Fluid, and Mucus in the Rat Colon in Vivo

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Influence of Vasoactive Intestinal Peptide, Secretin, and Ala4, Val5-Secretin on the Net Movements of Electrolytes, Fluid, and Mucus in the Rat Colon in Vivo

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Influence of Vasoactive Intestinal Peptide, Secretin, and Ala⁴, Val⁵-Secretin on the Net Movements of Electrolytes, Fluid, and Mucus in the Rat Colon in Vivo