Olsalazine Does Not Increase the Bile Acid Losses in Subjects with a Permanent Ileostomy

G. Järnerot Dept. of Medicine, Örebro Medical Center Hospital, Örebro, Sweden; Division of Gastroenterology, Örebro Medical Center Hospital, Örebro, Sweden; Dept. of Nuclear Medicine, Örebro Medical Center Hospital, Örebro, Sweden; Dept. of Medicine, Eskilstuna Central Hospital, Eskilstuna, Sweden

H. Sandberg-Gertzén Dept. of Medicine, Örebro Medical Center Hospital, Örebro, Sweden; Division of Gastroenterology, Örebro Medical Center Hospital, Örebro, Sweden; Dept. of Nuclear Medicine, Örebro Medical Center Hospital, Örebro, Sweden; Dept. of Medicine, Eskilstuna Central Hospital, Eskilstuna, Sweden

P. Tobiasson Dept. of Medicine, Örebro Medical Center Hospital, Örebro, Sweden; Division of Gastroenterology, Örebro Medical Center Hospital, Örebro, Sweden; Dept. of Nuclear Medicine, Örebro Medical Center Hospital, Örebro, Sweden; Dept. of Medicine, Eskilstuna Central Hospital, Eskilstuna, Sweden

K. J. Vikterlöf Dept. of Medicine, Örebro Medical Center Hospital, Örebro, Sweden; Division of Gastroenterology, Örebro Medical Center Hospital, Örebro, Sweden; Dept. of Nuclear Medicine, Örebro Medical Center Hospital, Örebro, Sweden; Dept. of Medicine, Eskilstuna Central Hospital, Eskilstuna, Sweden

Abstract

Olsalazine is a novel compound presently under development for the treatment of ulcerative colitis. Olsalazine sometimes causes diarrhoea; one of the possible explanations could be an increased load of bile acids in the colon. Bile acid ileostomy output was therefore measured enzymatically and after oral administration of tauro-23-[⁷⁵Se]selena-25-homocholic acid (SeHCAT) in eight subjects during intake of placebo or olsalazine. The bile acid output showed great individual variations during both treatment periods, but there was no indication that olsalazine interfered with bile acid handling in the terminal ileum.

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Olsalazine Does Not Increase the Bile Acid Losses in Subjects with a Permanent Ileostomy

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Olsalazine Does Not Increase the Bile Acid Losses in Subjects with a Permanent Ileostomy

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