Na⁺/H⁺ Ion-Exchange Property of Postmortem Human Gastric Mucus

L. Thomsen Dept. of Medicine, University of Auckland Medical School, Auckland, New Zealand; Dept. of Gastroenterology, Veterans Administration Hospital, Seattle, Washington, USA

C. Tasman-Jones Dept. of Medicine, University of Auckland Medical School, Auckland, New Zealand; Dept. of Gastroenterology, Veterans Administration Hospital, Seattle, Washington, USA

K. Maher Dept. of Medicine, University of Auckland Medical School, Auckland, New Zealand; Dept. of Gastroenterology, Veterans Administration Hospital, Seattle, Washington, USA

P. Wiggins Dept. of Medicine, University of Auckland Medical School, Auckland, New Zealand; Dept. of Gastroenterology, Veterans Administration Hospital, Seattle, Washington, USA

S. Lee Dept. of Medicine, University of Auckland Medical School, Auckland, New Zealand; Dept. of Gastroenterology, Veterans Administration Hospital, Seattle, Washington, USA

A. Morris Dept. of Medicine, University of Auckland Medical School, Auckland, New Zealand; Dept. of Gastroenterology, Veterans Administration Hospital, Seattle, Washington, USA

Abstract

The Na⁺/H⁺ ion-exchange property of human gastric mucus and its relationship to age has been studied. Mucus was collected from 40 postmortem human stomachs (age range, 21-83 years) within 24 h of traumatic death. Twenty-one stomachs (age range, 21-76 years) were free of Campylobacter pylori infection and histologic gastritis. Mucus from these stomachs was consistently a cation exchanger at pH 6 in an in vitro system. The cation-exchange capacity of mucus from seven stomachs within the age range 55-70 years was 50% less than the cation-exchange capacity of mucus from eight stomachs within the age range 20-35 years. This study shows that human gastric mucus at pH 6 is a cation exchanger and that the ion-exchange capacity decreases with age.

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Na⁺/H⁺ Ion-Exchange Property of Postmortem Human Gastric Mucus

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Na⁺/H⁺ Ion-Exchange Property of Postmortem Human Gastric Mucus