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Original Article

Regulation of Receptors on Parietal Cells on Acid Secretion

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Pages 22-33 | Published online: 08 Jul 2009
 

Abstract

Four types of receptors have so far been identified on the parietal cell: receptors for gastrin, acetylcholine, and histamine, whose activation leads to stimulation of acid secretion, and receptors for prostaglandins of the E series, whose activation leads to inhibition of acid secretion. Postreceptor events following drug-receptor interaction include mobilization of calcium ions and cAMP formation. Moreover, a number of putative receptors (for somatostatin, CCK, adenosine, secretin, etc.) have been hypothesized, even though definite evidence is still lacking. Finally, other substances may influence gastric acid secretion in a positive or negative way, but no evidence for an involvement of specific receptors on the parietal cells is available so far.

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