![Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5944/TOC-Subject-Sample-2021-Medicine-Dentistry-Nursing-Allied-Health.jpg"})
Abstract
The role of both sulfhydryl groups and endogenous prostaglandins in the protective effect of 5-adenosylmethionine against ethanol-induced gastric mucosal damage was studied in rats. Drugs were administered subcutaneously or intragastrically to fasted rats 30 or 60 min before 100% ethanol (1 ml/rat), and mucosal lesions were measured planimetrically 1 h later. The gastric mucosal protection given by 5-adenosylmethionine or by 20% ethanol (adaptive protection) was significantly diminished by pre-treatment of rats with the sulfhydryl blocker iodoacetamide or with the cyclooxygenase inhibitor indomethacin. The protective effect of 5-adenosylmethionine could be totally abolished only by pretreatment with the combination of iodoacetamide and indomethacin. Our present data suggest that endogenous release of prostaglandins and sulfhydryl groups may play a role in the protective actions of both 5-adenosylmethionine and 20% ethanol (adaptive protection) against ethanol-induced gastric mucosal damage.