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Scandinavian Journal of Gastroenterology Volume 24, 1989 - Issue 10
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Original Article

Effect of Pirenzepine on Aminopyrine Uptake by Isolated Guinea Pig Parietal Cells

N. Tani Dept. of Internal Medicine, School of Medicine, Tokai University, Isehara, Kanagawa Prefecture, Japan
,
Y. Watanabe Dept. of Internal Medicine, School of Medicine, Tokai University, Isehara, Kanagawa Prefecture, Japan
,
N. Mutoh Dept. of Internal Medicine, School of Medicine, Tokai University, Isehara, Kanagawa Prefecture, Japan
,
H. Karasawa Dept. of Internal Medicine, School of Medicine, Tokai University, Isehara, Kanagawa Prefecture, Japan
,
M. Hara Dept. of Internal Medicine, School of Medicine, Tokai University, Isehara, Kanagawa Prefecture, Japan
&
T. Miwa Dept. of Internal Medicine, School of Medicine, Tokai University, Isehara, Kanagawa Prefecture, Japan
Pages 1159-1162 | Received 24 Nov 1988, Accepted 12 Jun 1989, Published online: 08 Jul 2009
 
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Abstract

The inhibitory action of pirenzepine on acid secretion of isolated guinea pig parietal cells was investigated by the aminopyrine method. Pirenzepine markedly inhibited acid secretion of isolated parietal cells induced by carbachol in a dose-dependent manner but showed no inhibition on acid secretion stimulated by histamine. These results may suggest a direct action of pirenzepine on muscarinic receptors in parietal cells.

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