11
Views
6
CrossRef citations to date
0
Altmetric
Original Article

Polyamines in Human Gastric and Esophageal Cancer

, , &
Pages 1193-1199 | Received 22 Mar 1989, Accepted 11 May 1989, Published online: 08 Jul 2009
 

Abstract

Total, free, and acetylated polyamine concentrations were investigated in gastric or esophageal tissue, serum, and urine of 40 patients with gastric and 16 patients with esophageal cancer, 40 patients with non-malignant gastrointestinal diseases, and 30 healthy volunteers by means of automated reversed-phase liquid chromatography. In both types of carcinoma polyamine levels were highly elevated in tissue, serum, and urine as compared with healthy controls, which supports the concept that polyamines play an important role in proliferating tissues. However, non-malignant gastrointestinal diseases partly showed similar elevations. A significant linear correlation of polyamines in both carcinomas was found for erythrocyte sedimentation rate but not for tumor stage, tumor size, localization, carcinoembryonic antigen, CA 19–9, and CA 125. It is concluded that owing to its low specificity, polyamine determination in serum and urine has no clinical relevance in the screening for gastric or esophageal carcinoma.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.