Serum Anti-gliadin Antibody Profile in Childhood Protracted Diarrhoea Due to Coeliac Disease and Other Causes in a Developing Country

V. Khoshoo Dept. of Paediatrics, Division of Gastroenterology and Enteric Infections, All India Institute of Medical Sciences, New Delhi, India, and Dept. of Paediatrics, S:t Goran's Hospital, Karolinska Institute, Stockholm, Sweden

M. K. Bhan Dept. of Paediatrics, Division of Gastroenterology and Enteric Infections, All India Institute of Medical Sciences, New Delhi, India, and Dept. of Paediatrics, S:t Goran's Hospital, Karolinska Institute, Stockholm, Sweden

S. Puri Dept. of Paediatrics, Division of Gastroenterology and Enteric Infections, All India Institute of Medical Sciences, New Delhi, India, and Dept. of Paediatrics, S:t Goran's Hospital, Karolinska Institute, Stockholm, Sweden

R. Jain Dept. of Paediatrics, Division of Gastroenterology and Enteric Infections, All India Institute of Medical Sciences, New Delhi, India, and Dept. of Paediatrics, S:t Goran's Hospital, Karolinska Institute, Stockholm, Sweden

S. Jayashree Dept. of Paediatrics, Division of Gastroenterology and Enteric Infections, All India Institute of Medical Sciences, New Delhi, India, and Dept. of Paediatrics, S:t Goran's Hospital, Karolinska Institute, Stockholm, Sweden

S. Bhatnagar Dept. of Paediatrics, Division of Gastroenterology and Enteric Infections, All India Institute of Medical Sciences, New Delhi, India, and Dept. of Paediatrics, S:t Goran's Hospital, Karolinska Institute, Stockholm, Sweden

R. Kumar Dept. of Paediatrics, Division of Gastroenterology and Enteric Infections, All India Institute of Medical Sciences, New Delhi, India, and Dept. of Paediatrics, S:t Goran's Hospital, Karolinska Institute, Stockholm, Sweden

G. Stintzing Dept. of Paediatrics, Division of Gastroenterology and Enteric Infections, All India Institute of Medical Sciences, New Delhi, India, and Dept. of Paediatrics, S:t Goran's Hospital, Karolinska Institute, Stockholm, Sweden

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Abstract

Serum anti-gliadin antibody (AGA) titres were estimated by diffusion in a gel enzyme-linked immunosorbent assay in children with coeliac disease (n = 11), protracted diarrhoea of non-coeliac causes (n = 110), acute gastroenteritis (n = 20), protein energy malnutrition (n = 20), and asymptomatic, well-nourished children (n = 66). The mean IgG and IgA AGA titres were significantly higher (p < 0.001) in children with coeliac disease than in any other groups. There was no significant difference (p ± 0.01) in AGA titres in relation to age, nutritional status, or severity of villous injury. In patients with coeliac disease AGA titres showed a good correlation with disease activity. The specificity and sensitivity of the assay are discussed.

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Serum Anti-gliadin Antibody Profile in Childhood Protracted Diarrhoea Due to Coeliac Disease and Other Causes in a Developing Country

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Serum Anti-gliadin Antibody Profile in Childhood Protracted Diarrhoea Due to Coeliac Disease and Other Causes in a Developing Country

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