Serum Platelet-Activating Factor Acetylhydrolase Activity in Rats with Gastric Ulcers Induced by Water-Immersion Stress

K. Fujimura Third Department of Internal Medicine, Department of Medical Chemistry, Kansai Medical School, Osaka, Japan; Department of Biochemistry, School of Pharmaceutical Science, University of Shizuoka, Shizuoka, Japan

J. Sugatani Third Department of Internal Medicine, Department of Medical Chemistry, Kansai Medical School, Osaka, Japan; Department of Biochemistry, School of Pharmaceutical Science, University of Shizuoka, Shizuoka, Japan

M. Miwa Third Department of Internal Medicine, Department of Medical Chemistry, Kansai Medical School, Osaka, Japan; Department of Biochemistry, School of Pharmaceutical Science, University of Shizuoka, Shizuoka, Japan

T. Mizuno Third Department of Internal Medicine, Department of Medical Chemistry, Kansai Medical School, Osaka, Japan; Department of Biochemistry, School of Pharmaceutical Science, University of Shizuoka, Shizuoka, Japan

Y. Sameshima Third Department of Internal Medicine, Department of Medical Chemistry, Kansai Medical School, Osaka, Japan; Department of Biochemistry, School of Pharmaceutical Science, University of Shizuoka, Shizuoka, Japan

K. Saito Third Department of Internal Medicine, Department of Medical Chemistry, Kansai Medical School, Osaka, Japan; Department of Biochemistry, School of Pharmaceutical Science, University of Shizuoka, Shizuoka, Japan

Abstract

Platelet-activating factor (PAF) acetylhydrolase is an enzyme which hydrolyzes PAF to yield inactive lysoPAF. This study focused on the influence of water-immersion stress on serum PAF acetylhydrolase activity. The enzyme activity was determined by measurement of [³H]acetate produced from l-O-alkyl-2-[³H]acetyl-sn-glycero-3-phosphocholine upon precipitation of the complex of the radioactive substrate and albumin with trichloroacetic acid. The onset of water-immersion stress caused ‘the devefopment of gastric fesions associated’ with a significant increase in serum PAF acetylhydrolase activity. Serum PAF acetylhydrolase may leak into the blood from some tissues in rats with gastric injury induced by water-immersion stress and might control the action of PAF.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Serum Platelet-Activating Factor Acetylhydrolase Activity in Rats with Gastric Ulcers Induced by Water-Immersion Stress

Information for

Open access

Opportunities

Help and information

Serum Platelet-Activating Factor Acetylhydrolase Activity in Rats with Gastric Ulcers Induced by Water-Immersion Stress

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature