Gastric Mucosal Damage Induced in Rats by Intravenous Administration of Platelet-Activating Factor

T. Binnaka Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan

T. Yamaguchi Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan

J. Hirohara Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan

A. Hiramatsu Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan

T. Mizuno Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan

Y. Sameshima Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan

Abstract

We examined the time courses for gastric mucosal hemodynamics and lipid peroxides after intravenous infusion of PAF (platelet-activating factor). The gastric mucosal hemodynamics were continuously monitored by laser-Doppler flowmetry and reflectance spectrophotometry during 20 min infusion of PAF and the subsequent 60 min. Gastric mucosal damage was assessed by microscopical scoring and measurement of thiobarbituric acid (TBA) reactants. Intravenous infusion of PAF caused macroscopical gastric mucosal damage, hemodynamic disturbance, a reduction in blood pressure and elevation of TBA reactants. These changes did not recover to control levels, even at 60 min after PAF infusion. The mucosal injury caused by the hemodynamic disturbance (congestion) was related to the elevation of TBA reactants, that reflect lipid peroxidation and oxygen-derived free radicals.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Gastric Mucosal Damage Induced in Rats by Intravenous Administration of Platelet-Activating Factor

Information for

Open access

Opportunities

Help and information

Gastric Mucosal Damage Induced in Rats by Intravenous Administration of Platelet-Activating Factor

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature