Effect of Diethyldithiocarbamate on Gastric and Duodenal Mucosal Blood Flow and Vascular Permeability in Rats

S. Teramura Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan; Kyoto National Hospital, Kyoto, Japan

M. Murakami Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan; Kyoto National Hospital, Kyoto, Japan

H. Saita Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan; Kyoto National Hospital, Kyoto, Japan

Jk. Yoo Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan; Kyoto National Hospital, Kyoto, Japan

S. Kusaka Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan; Kyoto National Hospital, Kyoto, Japan

K. Matsuo Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan; Kyoto National Hospital, Kyoto, Japan

T. Kita Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan; Kyoto National Hospital, Kyoto, Japan

T. Miyake Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan; Kyoto National Hospital, Kyoto, Japan

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Abstract

Diethyldithiocarbamate (DDC), an inhibitor of superoxide dismutase, produced ulceration in the proximal duodenum of rats, and erosions or ulcers in the stomach. DDC given s. c. at 1.5g/kg increased duodenal and gastric vascular permeability, and reduced blood flow. The decrease in gastric blood flow caused by DDC was attenuated by pretreatment with superoxide dismutase, and significantly inhibited by a xanthine oxidase inhibitor, allopurinol. It is suggested that the superoxide and other radicals damage the mucosal vasculature, and play a role in the pathogenesis of gastric and duodenal mucosal lesions.

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Effect of Diethyldithiocarbamate on Gastric and Duodenal Mucosal Blood Flow and Vascular Permeability in Rats

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Effect of Diethyldithiocarbamate on Gastric and Duodenal Mucosal Blood Flow and Vascular Permeability in Rats

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