Changes in Levels of Mucosal Glycoprotein on Cysteamine-Induced Duodenal Ulcers in Rats

K. Koga Department of Internal Medicine, Tokyo Medical College, Tokyo, Japan

Y. Nonaka Department of Internal Medicine, Tokyo Medical College, Tokyo, Japan

T. Kawai Department of Internal Medicine, Tokyo Medical College, Tokyo, Japan

T. Seki Department of Internal Medicine, Tokyo Medical College, Tokyo, Japan

H. Kon Department of Internal Medicine, Tokyo Medical College, Tokyo, Japan

M. Tsurui Department of Internal Medicine, Tokyo Medical College, Tokyo, Japan

H. Ikeda Department of Internal Medicine, Tokyo Medical College, Tokyo, Japan

Y. Harada Department of Internal Medicine, Tokyo Medical College, Tokyo, Japan

T. Saito Department of Internal Medicine, Tokyo Medical College, Tokyo, Japan

S. Ashizawa Department of Internal Medicine, Tokyo Medical College, Tokyo, Japan

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Abstract

Duodenal ulcers were induced in rats by cysteamine administration. Time-course changes in duodenal hexo-samine, blood flow and intragastric pH were measured, as well as changes in the susceptibility of Brunner's glands to concanavalin A (Con A) staining. Hexosamine contents in the duodenum decreased significantly at 5 and 24 h. In the control group, Brunner's glands were stained brown using Con A staining. One day after cysteamine administration, the extent of Con A staining markedly decreased. At 3 and 7 days, gland susceptibility to staining was essentially the same as that of the control group.

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Changes in Levels of Mucosal Glycoprotein on Cysteamine-Induced Duodenal Ulcers in Rats

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Changes in Levels of Mucosal Glycoprotein on Cysteamine-Induced Duodenal Ulcers in Rats

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