Inhibitory Effect of Peptide YY on Gastric Acid Output in Rats

Y. Hashimoto First Department of Surgery, Kobe University School of Medicine, Kobe, Japan; Department of General Surgery, Beijing Hospital, China; Department of Surgery, Labor Welfare Corporation Kobe Rosai Hospital, Kobe, Japan

I. Sano First Department of Surgery, Kobe University School of Medicine, Kobe, Japan; Department of General Surgery, Beijing Hospital, China; Department of Surgery, Labor Welfare Corporation Kobe Rosai Hospital, Kobe, Japan

Y. Nagahata First Department of Surgery, Kobe University School of Medicine, Kobe, Japan; Department of General Surgery, Beijing Hospital, China; Department of Surgery, Labor Welfare Corporation Kobe Rosai Hospital, Kobe, Japan

Z T. Wang First Department of Surgery, Kobe University School of Medicine, Kobe, Japan; Department of General Surgery, Beijing Hospital, China; Department of Surgery, Labor Welfare Corporation Kobe Rosai Hospital, Kobe, Japan

A. Itoh First Department of Surgery, Kobe University School of Medicine, Kobe, Japan; Department of General Surgery, Beijing Hospital, China; Department of Surgery, Labor Welfare Corporation Kobe Rosai Hospital, Kobe, Japan

K. Takeda First Department of Surgery, Kobe University School of Medicine, Kobe, Japan; Department of General Surgery, Beijing Hospital, China; Department of Surgery, Labor Welfare Corporation Kobe Rosai Hospital, Kobe, Japan

T. Ichihara First Department of Surgery, Kobe University School of Medicine, Kobe, Japan; Department of Surgery, Labor Welfare Corporation Kobe Rosai Hospital, Kobe, Japan; Department of General Surgery, Beijing Hospital, China

H. Moritomo First Department of Surgery, Kobe University School of Medicine, Kobe, Japan; Department of General Surgery, Beijing Hospital, China; Department of Surgery, Labor Welfare Corporation Kobe Rosai Hospital, Kobe, Japan

T. Urakawa First Department of Surgery, Kobe University School of Medicine, Kobe, Japan; Department of General Surgery, Beijing Hospital, China; Department of Surgery, Labor Welfare Corporation Kobe Rosai Hospital, Kobe, Japan

Y. Saitoh First Department of Surgery, Kobe University School of Medicine, Kobe, Japan; Department of General Surgery, Beijing Hospital, China; Department of Surgery, Labor Welfare Corporation Kobe Rosai Hospital, Kobe, Japan

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Abstract

The administration of peptide YY (PYY: 0.8, 1.6 and 3.2 nmol/kg/h, i. v.) to fasting rats inhibited not only baclofen (2 mg/kg, s. c.)-stimulated gastric acid output and gastric mucosal blood flow, but also pentagastrin (8 ug/kg/h, i. v.)-stimulated gastric acid output. PYY (3.2 nmol/kg/h) reduced baclofen-induced acid output more than pentagastrin-induced acid output, i. e., by 61.8 ± 11.5% compared to 35.3 ± 8.2%. PYY inhibited acetylcholine (ACh) release from cholinergic nerve endings of gastric body evoked by electrical transmural stimulation (ETS: 1 msec, 10 V, 3 Hz, 30 sec) by 47.2 ± 3.5 %. The mechanism of the inhibitory effect of PYY on gastric acid output seems to involve decreased gastric mucosal blood flow and reduced ACh release from cholinergic nerves.

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Inhibitory Effect of Peptide YY on Gastric Acid Output in Rats

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Inhibitory Effect of Peptide YY on Gastric Acid Output in Rats

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