Augmentation of the Gastric Mucosal Defense Mechanism Induced by KW-5805, a Novel Antiulcer Agent

H. Tanaka Pharm. Res. Lab., Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan; First Dept. of Medicine, Osaka University Medical School, Osaka, Japan

N. Kosaka Pharm. Res. Lab., Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan; First Dept. of Medicine, Osaka University Medical School, Osaka, Japan

A. Tomaru Pharm. Res. Lab., Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan; First Dept. of Medicine, Osaka University Medical School, Osaka, Japan

K. Shuto Pharm. Res. Lab., Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan; First Dept. of Medicine, Osaka University Medical School, Osaka, Japan

T. Ogihara Pharm. Res. Lab., Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan; First Dept. of Medicine, Osaka University Medical School, Osaka, Japan

N. Sato Pharm. Res. Lab., Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan; First Dept. of Medicine, Osaka University Medical School, Osaka, Japan

Abstract

KW-5805 (a new antiulcer agent), given p. o. at 30 mg/kg to rats, significantly increased the amount of gastric adherent mucus and mucosal glycoproteins. Gastric mucosal glucosamine synthetase activity was significantly enhanced by KW-5805 (30 mg/kg, p. o.). KW-5805 (10, 30 mg/kg, p. o.) significantly suppressed the decrease of gastric mucosal blood volume and oxygen sufficiency induced by hemorrhagic shock. The agent also significantly inhibited the extravasation of Evans blue into the gstric mucosa after ischemia-reinfusion. In conclusion, KW-5805 increased biosynthesis, storage and secretion of gastric mucus and improved the gastric mucosal hemodynamics.

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Augmentation of the Gastric Mucosal Defense Mechanism Induced by KW-5805, a Novel Antiulcer Agent

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Augmentation of the Gastric Mucosal Defense Mechanism Induced by KW-5805, a Novel Antiulcer Agent

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