The Role of the Sympathetic Nervous System in Cysteamine-Induced Gastric Lesions in Rats

S. Shikuwa Department of Pathology, Atomic Disease Institute, Nagasaki University School of Medicine, and Nagasaki Municipal Hospital, Nagasaki, Japan

S. Naito Department of Pathology, Atomic Disease Institute, Nagasaki University School of Medicine, and Nagasaki Municipal Hospital, Nagasaki, Japan

H. Chaotien Department of Pathology, Atomic Disease Institute, Nagasaki University School of Medicine, and Nagasaki Municipal Hospital, Nagasaki, Japan

K. Shichijo Department of Pathology, Atomic Disease Institute, Nagasaki University School of Medicine, and Nagasaki Municipal Hospital, Nagasaki, Japan

Y. Kawase Department of Pathology, Atomic Disease Institute, Nagasaki University School of Medicine, and Nagasaki Municipal Hospital, Nagasaki, Japan

M. Ito Department of Pathology, Atomic Disease Institute, Nagasaki University School of Medicine, and Nagasaki Municipal Hospital, Nagasaki, Japan

I. Serine Department of Pathology, Atomic Disease Institute, Nagasaki University School of Medicine, and Nagasaki Municipal Hospital, Nagasaki, Japan

K. Imamura Department of Pathology, Atomic Disease Institute, Nagasaki University School of Medicine, and Nagasaki Municipal Hospital, Nagasaki, Japan

show all

Abstract

Cysteamine - HC1, when administered subcutaneously at 350 mg/kg, consistently induced severe gastric lesions in Wistar Kyoto rats (WKY), but not in spontaneously hypertensive rats (SHR). In both WKY and SHR, visible ulcers could not be induced in the duodenum in response to cysteamine. It appears that the stomach and duodenum of SHR are resistant to cysteamine due to hyperfunctioning of the sympathetic nervous system.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

The Role of the Sympathetic Nervous System in Cysteamine-Induced Gastric Lesions in Rats

Information for

Open access

Opportunities

Help and information

The Role of the Sympathetic Nervous System in Cysteamine-Induced Gastric Lesions in Rats

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature