Effect of Plasmin Inhibitors on Gastric Mucosal Permeability in Rats

J. K. Yoo Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan; National Kyoto Hospital, Kyoto, Japan

M. Murakami Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan; National Kyoto Hospital, Kyoto, Japan

S. Teramura Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan; National Kyoto Hospital, Kyoto, Japan

H. Saita Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan; National Kyoto Hospital, Kyoto, Japan

S. Kusaka Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan; National Kyoto Hospital, Kyoto, Japan

K. Matsuo Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan; National Kyoto Hospital, Kyoto, Japan

T. Kita Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan; National Kyoto Hospital, Kyoto, Japan

T. Miyake Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan; National Kyoto Hospital, Kyoto, Japan

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Abstract

We examined the protective effect of plasmin inhibitors on gastric mucosal vascular permeability in rats. Tran-examic acid and aminocaproic acid significantly inhibited the increase in vascular permeability and macroscopic gastric mucosal lesions induced by 50 % ethanol and 1 % ammonia. The protective effect afforded by plasmin inhibitors was not affected by pretreatment with in-domethacin. Our results show that plasmin inhibitors inhibit the increase in gastric vascular permeability and suggest that plasmin may play an important role in the pathogenesis of gastric mucosal damage.

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Effect of Plasmin Inhibitors on Gastric Mucosal Permeability in Rats

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Effect of Plasmin Inhibitors on Gastric Mucosal Permeability in Rats

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