Rioprostil, a New Prostaglandin E₁, Prevents Cyclosporin A-Induced Damage to Endocrine and Exocrine Pancreas

M. Müller Division of Gastroenterology, Department of Medicine, Department of Surgery, University of Essen and Department of Pathology, University of Hamburg, FRG

H. Degenhardt Division of Gastroenterology, Department of Medicine, Department of Surgery, University of Essen and Department of Pathology, University of Hamburg, FRG

K. Bergmann Division of Gastroenterology, Department of Medicine, Department of Surgery, University of Essen and Department of Pathology, University of Hamburg, FRG

H. Coone Division of Gastroenterology, Department of Medicine, Department of Surgery, University of Essen and Department of Pathology, University of Hamburg, FRG

M. Löhr Division of Gastroenterology, Department of Medicine, Department of Surgery, University of Essen and Department of Pathology, University of Hamburg, FRG

G. Klöppel Division of Gastroenterology, Department of Medicine, Department of Surgery, University of Essen and Department of Pathology, University of Hamburg, FRG

H. Goebell Division of Gastroenterology, Department of Medicine, Department of Surgery, University of Essen and Department of Pathology, University of Hamburg, FRG

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Abstract

The possibility that rioprostil can prevent cyclosporin A-induced damage to the pancreas is investigated. Cyclosporin A is given to rats once daily intragastrically in doses of 5,10 and 20 mg/kg body weight. These doses cause dose dependent significant reduction of insulin release and enzyme secretion from the arterially perfused isolated pancreas. The subcutaneous injection of rioprostil, 15 μg/kg twice daily, could completely prevent the effects of 5 mg/kg cyclosporin A on insulin release and could also afford significant protection from the effects of 10 and 20 mg/kg cyclosporin A on both insulin release and enzyme secretion. The cytoprotective action of rioprostil on the pancreas may have therapeutic implications.

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Rioprostil, a New Prostaglandin E₁, Prevents Cyclosporin A-Induced Damage to Endocrine and Exocrine Pancreas

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Rioprostil, a New Prostaglandin E1, Prevents Cyclosporin A-Induced Damage to Endocrine and Exocrine Pancreas

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Rioprostil, a New Prostaglandin E₁, Prevents Cyclosporin A-Induced Damage to Endocrine and Exocrine Pancreas