Effect of Rioprostil, a Methyl-Prostaglandin E₁ on Plasma Level and Renal Excretion of β-Acetyldigoxin: Conclusion

Abstract

A single oral dose of rioprostil, a synthetic methyl-prostaglandin E1, together with or 2 h before ingestion of 0.8 mg β-acetyldigoxin significantly delays the rate but does not change the extent of β-acetyldigoxin absorption. However, repeated evening doses of rioprostil do not alter either the glycoside steady-state plasma levels or renal excretion.

Key Words:

• β-Acetyldigoxin
• plasma level
• prostaglandin E₁
• renal excretion
• rioprostil