Oesophageal Motility and Lower Oesophageal Sphincter Competence in Progressive Systemic Sclerosis and Localized Scleroderma

G. Zaninotto Institute of Surgical Semeiotics, Institute of Dermatology, Surgical Clinic I, and Institute of Internal Medicine, University of Padua, Padua, Italy

A. Peserico Institute of Surgical Semeiotics, Institute of Dermatology, Surgical Clinic I, and Institute of Internal Medicine, University of Padua, Padua, Italy

M. Costantini Institute of Surgical Semeiotics, Institute of Dermatology, Surgical Clinic I, and Institute of Internal Medicine, University of Padua, Padua, Italy

L. Salvador Institute of Surgical Semeiotics, Institute of Dermatology, Surgical Clinic I, and Institute of Internal Medicine, University of Padua, Padua, Italy

R. Rondinone Institute of Surgical Semeiotics, Institute of Dermatology, Surgical Clinic I, and Institute of Internal Medicine, University of Padua, Padua, Italy

A. Roveran Institute of Surgical Semeiotics, Institute of Dermatology, Surgical Clinic I, and Institute of Internal Medicine, University of Padua, Padua, Italy

G. Piasentin Institute of Surgical Semeiotics, Institute of Dermatology, Surgical Clinic I, and Institute of Internal Medicine, University of Padua, Padua, Italy

S. Glorioso Institute of Surgical Semeiotics, Institute of Dermatology, Surgical Clinic I, and Institute of Internal Medicine, University of Padua, Padua, Italy

S. Merigliano Institute of Surgical Semeiotics, Institute of Dermatology, Surgical Clinic I, and Institute of Internal Medicine, University of Padua, Padua, Italy

E. Ancona Institute of Surgical Semeiotics, Institute of Dermatology, Surgical Clinic I, and Institute of Internal Medicine, University of Padua, Padua, Italy

A. Peracchia Institute of Surgical Semeiotics, Institute of Dermatology, Surgical Clinic I, and Institute of Internal Medicine, University of Padua, Padua, Italy

show all

Abstract

Oesophageal motility and lower oesophageal sphincter (LOS) competence were investigated in 13 patients with progressive systemic sclerosis (PSS) and in 16 patients with localized scleroderma (LS) by means of oesophageal manometry and 24-h pH monitoring of the distal oesophagus. Results were compared with those of a control group consisting of asymptomatic volunteers. Marked abnormalities in oesophageal motility and in acid exposure in the distal oesophagus were observed in PSS patients only. the mean resting pressure of the LOS was 10.1 ± 1.5 mmHg in PSS, 21.4 ± 1.1 mmHg in LS, and 23.8 ± 2.0 mmHg in asymptomatic controls. Overall sphincter length was 24.1 ± 3.4 mm in PSS, 31.1 ± 1.6 mm in LS, and 39.0 ± 2.0 mm in the control group. Sphincter abdominal length was 12.1 ± 2 mm, 15.4 ± 1 mm, and 25.0 ± 1 mm, respectively. the amplitude and duration of oesophageal waves were markedly reduced at 5, 10, and 15 cm above the LOS in PSS patients, with only the upper part of their gullet being spared. An abnormal acid exposure in the distal oesophagus was observed in 84.6% of PSS patients, whereas only 18.2% (2 of 11) of pH-tested LS patients had an abnormal 24-h pH test. These data show that a marked oesophageal involvement is present only in the systemic form of scleroderma. Oesophageal tests may be useful for a circumstantial diagnosis whenever the diagnosis of PSS is uncertain; however, their use does not seem to be justified as routine in patients with LS.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Oesophageal Motility and Lower Oesophageal Sphincter Competence in Progressive Systemic Sclerosis and Localized Scleroderma

Information for

Open access

Opportunities

Help and information

Oesophageal Motility and Lower Oesophageal Sphincter Competence in Progressive Systemic Sclerosis and Localized Scleroderma

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature