Significance of a Sonographic Secretin Test in the Diagnosis of Pancreatic Disease: Results of a Prospective Study

J. Glaser Medical Clinic and Outpatient Clinic, and Institute for Medical Information and Biomathematics, University of Münster, Münster, FRG

B. Högemann Medical Clinic and Outpatient Clinic, and Institute for Medical Information and Biomathematics, University of Münster, Münster, FRG

M. Schneider Medical Clinic and Outpatient Clinic, and Institute for Medical Information and Biomathematics, University of Münster, Münster, FRG

E. Hultsch Medical Clinic and Outpatient Clinic, and Institute for Medical Information and Biomathematics, University of Münster, Münster, FRG

N. Van Husen Medical Clinic and Outpatient Clinic, and Institute for Medical Information and Biomathematics, University of Münster, Münster, FRG

U. Gerlach Medical Clinic and Outpatient Clinic, and Institute for Medical Information and Biomathematics, University of Münster, Münster, FRG

Abstract

In a prospective study the pancreatic duct diameter was measured sonographically before and after secretin stimulation in 20 healthy controls and 59 patients with upper abdominal pain, weight loss, and/or diarrhea. Whereas healthy controls and patients without pancreatic disease after secretin stimulation showed a distinct pancreatic duct dilatation of more than 90% of basal duct diameter, no distinct secretin-induced duct enlargement was observed in most patients with chronic pancreatitis. Patients with circumscript pancreatic duct stenosis even had a marked and longer-lasting duct dilatation after stimulation. In patients with anomalies of the pancreatic duct system, no uniform response was found after secretin injection. In this study the sonographic secretin test showed a sensitivity of 92% and a specificity of 95% for diagnosis of chronic pancreatitis. The results confirm that this diagnostic method can be recommended as a reliable screening test for pancreatic disease.

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Significance of a Sonographic Secretin Test in the Diagnosis of Pancreatic Disease: Results of a Prospective Study

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Significance of a Sonographic Secretin Test in the Diagnosis of Pancreatic Disease: Results of a Prospective Study

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