Effect of Low-Dose Exogenous Secretin and Somatostatin on Pentagastrin-Stimulated Gastric Acid Secretion in Man

J. Olsen Dept. of Surgery D, Glostrup Hospital, Copenhagen; Dept. of Medical Gastroenterology, Sodense University Hospital, Odense; Institute of Medical Physiology C, The Panum Institute, University of Copenhagen, Copenhagen, Denmark

P. E. Mortensen Dept. of Surgery D, Glostrup Hospital, Copenhagen; Dept. of Medical Gastroenterology, Sodense University Hospital, Odense; Institute of Medical Physiology C, The Panum Institute, University of Copenhagen, Copenhagen, Denmark

O. B. Schaffalitzky de Muckadell Dept. of Surgery D, Glostrup Hospital, Copenhagen; Dept. of Medical Gastroenterology, Sodense University Hospital, Odense; Institute of Medical Physiology C, The Panum Institute, University of Copenhagen, Copenhagen, Denmark

J. J. Holst Dept. of Surgery D, Glostrup Hospital, Copenhagen; Dept. of Medical Gastroenterology, Sodense University Hospital, Odense; Institute of Medical Physiology C, The Panum Institute, University of Copenhagen, Copenhagen, Denmark

J. Christiansen Dept. of Surgery D, Glostrup Hospital, Copenhagen; Dept. of Medical Gastroenterology, Sodense University Hospital, Odense; Institute of Medical Physiology C, The Panum Institute, University of Copenhagen, Copenhagen, Denmark

Abstract

The inhibitory effect of intravenous infusion of secretin (0.05CUkg^-1h^-1) and somatostatin (60 pmolkg^-1 h^-1), given alone or in combination, on pentagastrin-stimulated (100 ng kg^-1 h^-1) acid secretion was studied in 10 healthy subjects. Secretin inhibited acid secretion by 54% (p <0.05), and somatostatin inhibited by 70% (p < 0.05). The combined infusion of secretin and somatostatin decreased acid output by 64% (p < 0.05). The differences between the three groups were not significant (p > 0.05). Median plasma concentrations of secretin and somatostatin were of the same magnitude as seen after duodenal acidification. The present study did not demonstrate any interaction between secretin and somatostatin in the inhibition of gastric acid secretion.

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Effect of Low-Dose Exogenous Secretin and Somatostatin on Pentagastrin-Stimulated Gastric Acid Secretion in Man

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Effect of Low-Dose Exogenous Secretin and Somatostatin on Pentagastrin-Stimulated Gastric Acid Secretion in Man

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