Study of 16,16-Dimethyl Prostaglandin E₂ for Prevention of Stress Ulcer after Hepatectomy of Experimental Cirrhotic Liver and Its Influence on Hepatic Regeneration

T. Urakawa Dept. of Clinical Gastroenterology, Kobe Rosai Hospital of the Labour Welfare Corporation; The First Dept. of Surgery, Kobe University School of Medicine, Kobe, Japan

Y. Azumi Dept. of Clinical Gastroenterology, Kobe Rosai Hospital of the Labour Welfare Corporation; The First Dept. of Surgery, Kobe University School of Medicine, Kobe, Japan

Y. Nagahata Dept. of Clinical Gastroenterology, Kobe Rosai Hospital of the Labour Welfare Corporation; The First Dept. of Surgery, Kobe University School of Medicine, Kobe, Japan

S. Matsui Dept. of Clinical Gastroenterology, Kobe Rosai Hospital of the Labour Welfare Corporation; The First Dept. of Surgery, Kobe University School of Medicine, Kobe, Japan

M. Nakamoto Dept. of Clinical Gastroenterology, Kobe Rosai Hospital of the Labour Welfare Corporation; The First Dept. of Surgery, Kobe University School of Medicine, Kobe, Japan

K. Takeda Dept. of Clinical Gastroenterology, Kobe Rosai Hospital of the Labour Welfare Corporation; The First Dept. of Surgery, Kobe University School of Medicine, Kobe, Japan

A. Itoh Dept. of Clinical Gastroenterology, Kobe Rosai Hospital of the Labour Welfare Corporation; The First Dept. of Surgery, Kobe University School of Medicine, Kobe, Japan

T. Ichihara Dept. of Clinical Gastroenterology, Kobe Rosai Hospital of the Labour Welfare Corporation; The First Dept. of Surgery, Kobe University School of Medicine, Kobe, Japan

H. Moritomo Dept. of Clinical Gastroenterology, Kobe Rosai Hospital of the Labour Welfare Corporation; The First Dept. of Surgery, Kobe University School of Medicine, Kobe, Japan

H. Kuroda Dept. of Clinical Gastroenterology, Kobe Rosai Hospital of the Labour Welfare Corporation; The First Dept. of Surgery, Kobe University School of Medicine, Kobe, Japan

Y. Saitoh Dept. of Clinical Gastroenterology, Kobe Rosai Hospital of the Labour Welfare Corporation; The First Dept. of Surgery, Kobe University School of Medicine, Kobe, Japan

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Abstract

The influence of 16,16-dimethyl prostaglandin E₂ (16,16-dm PGE₂; an agent used for the prevention of stress ulcer after hepatectomy of the cirrhotic liver) on liver regeneration after hepatectomy was studied in rats. The following results were obtained. Ulceration after the stress of 6 h of water immersion was markedly suppressed in rats treated with 30 r/kgof 16,16-dmPGE₂ as compared with the untreated controls. In animals that received hepatectomy alone, the gastric pH and gastric mucosal blood flow showed significant reduction from the preoperative levels. In animals that received hepatectomy plus 16,16-dmPGE₂ treatment the postoperative reduction in the gastric pH and gastric mucosal blood flow was suppressed, suggesting the effectiveness of 16,16-dmPGE₂ treatment in the prevention of stress ulcer after hepatectomy of the cirrhotic liver. The ³H-thymidine uptake percentage and thymidine activity 24 h after hepatectomy and the DN A content 30 h after hepatectomy were significantly higher in animals treated with 16,16-dmPGE₂ than in the untreated controls. In animals that were treated intraperitoneally with 50mg/kg of indo-methacin 6 h before hepatectomy the mitotic index 30 h after hepatectomy was markedly lower than that in untreated controls. This indomethacin-induced reduction in the mitotic index tended to be normalized by treatment with 16,16-dmPGE₂. These results suggest that 16,16-dmPGE₂ treatment effectively prevents stress ulcer and favorably affects hepatic regeneration after hepatectomy of the cirrhotic liver.

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Study of 16,16-Dimethyl Prostaglandin E₂ for Prevention of Stress Ulcer after Hepatectomy of Experimental Cirrhotic Liver and Its Influence on Hepatic Regeneration

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Study of 16,16-Dimethyl Prostaglandin E2 for Prevention of Stress Ulcer after Hepatectomy of Experimental Cirrhotic Liver and Its Influence on Hepatic Regeneration

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Study of 16,16-Dimethyl Prostaglandin E₂ for Prevention of Stress Ulcer after Hepatectomy of Experimental Cirrhotic Liver and Its Influence on Hepatic Regeneration