The Aetiology of Gastric Stump Carcinoma in the Rat

Abstract

This study investigated the aetiology of gastric stump carcinoma in the rat. These carcinomas were induced by duodenogastric reflux without the need to administer carcinogens. Carcinoma was only detected when pancreatic exocrine secretions were present in the reflux. Malignant change was associated with dysplasia but not intestinal metaplasia or adenocystic proliferation of glands. The extent of resection increased tumour yield, but a truncal vagototny did not. No difference was detected in intra-gastric pH, bacterial flora, or bile acid concentration between animals with and without carcinoma.

Key Words:

• Duodenogastric reflux
• gastric carcinoma
• rat