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Scandinavian Journal of Gastroenterology Volume 25, 1990 - Issue 10
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Original Article

Misoprostol Treatment Exacerbates Abdominal Discomfort in Patients with Non-Ulcer Dyspepsia and Erosive Prepyloric Changes: A Double-Blind, Placebo-Controlled, Multicentre Study

T. Hausken Medical Dept., Haukeland Hospital, Bergen; Medical Dept., Lovisenberg Hospital, Oslo; Medical Dept., Molde Hospital, Molde; Medical Dept., Hammerfest Hospital, Hammerfest; Medical Dept., Askim Hospital, Askim, Norway
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G. Stene-Larsen Medical Dept., Haukeland Hospital, Bergen; Medical Dept., Lovisenberg Hospital, Oslo; Medical Dept., Molde Hospital, Molde; Medical Dept., Hammerfest Hospital, Hammerfest; Medical Dept., Askim Hospital, Askim, Norway
,
O. Lange Medical Dept., Haukeland Hospital, Bergen; Medical Dept., Lovisenberg Hospital, Oslo; Medical Dept., Molde Hospital, Molde; Medical Dept., Hammerfest Hospital, Hammerfest; Medical Dept., Askim Hospital, Askim, Norway
,
O. Aronsen Medical Dept., Haukeland Hospital, Bergen; Medical Dept., Lovisenberg Hospital, Oslo; Medical Dept., Molde Hospital, Molde; Medical Dept., Hammerfest Hospital, Hammerfest; Medical Dept., Askim Hospital, Askim, Norway
,
T. Nerdrum Medical Dept., Haukeland Hospital, Bergen; Medical Dept., Lovisenberg Hospital, Oslo; Medical Dept., Molde Hospital, Molde; Medical Dept., Hammerfest Hospital, Hammerfest; Medical Dept., Askim Hospital, Askim, Norway
,
F. Hegbom Medical Dept., Haukeland Hospital, Bergen; Medical Dept., Lovisenberg Hospital, Oslo; Medical Dept., Molde Hospital, Molde; Medical Dept., Hammerfest Hospital, Hammerfest; Medical Dept., Askim Hospital, Askim, Norway
,
T. Schulz Medical Dept., Haukeland Hospital, Bergen; Medical Dept., Lovisenberg Hospital, Oslo; Medical Dept., Molde Hospital, Molde; Medical Dept., Hammerfest Hospital, Hammerfest; Medical Dept., Askim Hospital, Askim, Norway
&
A. Berstad Medical Dept., Haukeland Hospital, Bergen; Medical Dept., Lovisenberg Hospital, Oslo; Medical Dept., Molde Hospital, Molde; Medical Dept., Hammerfest Hospital, Hammerfest; Medical Dept., Askim Hospital, Askim, Norway
 show all
Pages 1028-1033 | Received 18 Jan 1990, Accepted 06 Apr 1990, Published online: 08 Jul 2009
 
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Abstract

One hundred and thirty-seven consecutive outpatients with non-ulcer dyspepsia (NUD) and erosive prepyloric changes (EPC) were randomly allocated to double-blind treatment with 400-μg misoprostol tablets twice daily or placebo for 4 weeks. Misoprostol had a significant worsening effect on epigastric pain, nausea, meteorism, lower abdominal pain, and diarrhoea, as compared with placebo. The fact that symptoms in patients with NUD and EPC were exacerbated by an antisecretory dose of misoprostol indicates that the symptoms are largely unrelated to gastric acid.

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