4
Views
16
CrossRef citations to date
0
Altmetric
Original Article

Growth Hormone Increases the Mass, the Collagenous Proteins, and the Strength of Rat Colon

, , &
Pages 1137-1143 | Received 02 Feb 1990, Accepted 10 May 1990, Published online: 08 Jul 2009
 

Abstract

The effect of growth hormone treatment on the left colon was investigated in 4-month-old Wistar rats. The animals were injected with saline (controls) or biosynthetic human growth hormone (b-hGH) in doses of 1.0 and 5.0 mg b-hGH/kg/day for 30 days. The total body weight of the rats injected with 1.0 mg b-hGH/kg/day did not differ from that of the control group, whereas the body weight of the rats injected with 5.0 mg b-hGH/kg/day was increased by 37% compared with the control group. The colonic dry weight per unit length was increased by 57% and 46% by 1.0 mg and 5.0 mg b-hGH/kg/day, respectively. The defatted dry weight was increased by 52% and 44%, respectively. The hydroxyproline content per unit length was increased by 31% and 23%, respectively. Furthermore, the biomechanical strength was increased by the b-hGH injections. No difference between the two b-hGH doses was found in any of the data.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.