Growth Hormone Increases the Mass, the Collagenous Proteins, and the Strength of Rat Colon

H. Christensen Dept. of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, Aarhus, Denmark; Institute for Experimental Clinical Research, University of Aarhus, Aarhus Kommunehospital, Aarhus, Denmark

P. Holmberg Jørgensen Dept. of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, Aarhus, Denmark; Institute for Experimental Clinical Research, University of Aarhus, Aarhus Kommunehospital, Aarhus, Denmark

H. Oxlund Dept. of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, Aarhus, Denmark; Institute for Experimental Clinical Research, University of Aarhus, Aarhus Kommunehospital, Aarhus, Denmark

S. Laurberg Dept. of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, Aarhus, Denmark; Institute for Experimental Clinical Research, University of Aarhus, Aarhus Kommunehospital, Aarhus, Denmark

Abstract

The effect of growth hormone treatment on the left colon was investigated in 4-month-old Wistar rats. The animals were injected with saline (controls) or biosynthetic human growth hormone (b-hGH) in doses of 1.0 and 5.0 mg b-hGH/kg/day for 30 days. The total body weight of the rats injected with 1.0 mg b-hGH/kg/day did not differ from that of the control group, whereas the body weight of the rats injected with 5.0 mg b-hGH/kg/day was increased by 37% compared with the control group. The colonic dry weight per unit length was increased by 57% and 46% by 1.0 mg and 5.0 mg b-hGH/kg/day, respectively. The defatted dry weight was increased by 52% and 44%, respectively. The hydroxyproline content per unit length was increased by 31% and 23%, respectively. Furthermore, the biomechanical strength was increased by the b-hGH injections. No difference between the two b-hGH doses was found in any of the data.

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Growth Hormone Increases the Mass, the Collagenous Proteins, and the Strength of Rat Colon

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Growth Hormone Increases the Mass, the Collagenous Proteins, and the Strength of Rat Colon

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