Effect of Gemfibrozil Administration on Biliary Lipid Secretion in Hyperlipidemic Patients

Abstract

Gemfibrozil, like clofibrate, is effective in lowering both serum cholesterol and triglycerides and in increasing high-density lipoproteins. The information available about its effects on biliary lipids is still limited, and conflicting results have been reported. In this study we evaluated the effect of gemfibrozil (1.2g/day) and clofibrate (2.0g/day), in a single-blind crossover design for 6 weeks with a 4-week washout period, on the biliary cholesterol saturation index (SI) in stimulated hepatic bile and on the hepatic secretion rate of biliary lipids in patients with hyper-lipidemia. Clofibrate increased cholesterol SI (from 1.70 ± 0.14 to 2.05 ± 0.24), whereas gemfibrozil decreased it (from 1.70 ± 0.14 to 1.54 ± 0.16). The results were not statistically significant. The hepatic secretion rate of cholesterol was significantly (p < 0.04) increased by clofibrate therapy, whereas it was significantly (p < 0.04) decreased after gemfibrozil; a significant (p < 0.04) decrease in the hepatic secretion rate of bile acids, bile acid pool size, and bile acid fecal excretion (p < 0.04) was also found after gemfibrozil administration. Gemfibrozil interferes extensively with bile acid metabolism, but it does not increase biliary cholesterol secretion, as clofibrate does. These results suggest that gemfibrozil does not seem to increase the risk of gallstone formation in patients with hyperlipidemia.

Key Words:

• Bile acid
• cholesterol
• clofibrate
• fibric acid
• gemfibrozil
• phospholipids