Action of Neurotensin on Meal-Stimulated Gastric Acid Secretion in the Dog

V. E. Eysselein Inflammatory Bowel Disease Center, Dept. of Gastroenterology, Harbor-UCLA Medical Center, Torrance, California, USA; Dept. of Gastroenterology and Surgery, University of Essen, Essen, FRG; California Biotechnology Inc., Mountain View, California, USA

W. H. Hesse Inflammatory Bowel Disease Center, Dept. of Gastroenterology, Harbor-UCLA Medical Center, Torrance, California, USA; Dept. of Gastroenterology and Surgery, University of Essen, Essen, FRG; California Biotechnology Inc., Mountain View, California, USA

G. A. Eberlein Inflammatory Bowel Disease Center, Dept. of Gastroenterology, Harbor-UCLA Medical Center, Torrance, California, USA; Dept. of Gastroenterology and Surgery, University of Essen, Essen, FRG; California Biotechnology Inc., Mountain View, California, USA

C. Koelbel Inflammatory Bowel Disease Center, Dept. of Gastroenterology, Harbor-UCLA Medical Center, Torrance, California, USA; Dept. of Gastroenterology and Surgery, University of Essen, Essen, FRG; California Biotechnology Inc., Mountain View, California, USA

W. Niebel Inflammatory Bowel Disease Center, Dept. of Gastroenterology, Harbor-UCLA Medical Center, Torrance, California, USA; Dept. of Gastroenterology and Surgery, University of Essen, Essen, FRG; California Biotechnology Inc., Mountain View, California, USA

H. Goebell Inflammatory Bowel Disease Center, Dept. of Gastroenterology, Harbor-UCLA Medical Center, Torrance, California, USA; Dept. of Gastroenterology and Surgery, University of Essen, Essen, FRG; California Biotechnology Inc., Mountain View, California, USA

Abstract

In six to nine mongrel dogs the effect of graded doses of intravenous neurotensin (188, 375, 750, and 1500 pmol/kg h) on acid secretion basally or stimulated by distention (by isotonic glucose), peptone (0.5. 1, and 4 g%), and pentagastrin was studied. Neurotensin did not affect acid secretion basally. stimulated by distention. or thc maximal peptone dose. However, when submaxiinal doses (0.5 and 1 g%) of peptone were instilled in the stomach, neurotensin stimulated the secretory response to intragastric peptone. This effect was observed in doses of intravenous neurotensin which mimicked circulating neurotensin concentrations after a standard test meal. Thus, neurotensin could be Considered a physiologic stimulant of acid secretion when protein is present in the stomach. The mechanism for this action of neurotensin is unknown but could be partly explained by an enhanced release of gastrin. The potentiating effect of neurotensin on peptone-stimulated acid sccretion coirld play a major role in gastric secretory function of the dog.

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Action of Neurotensin on Meal-Stimulated Gastric Acid Secretion in the Dog

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Action of Neurotensin on Meal-Stimulated Gastric Acid Secretion in the Dog

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