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Abstract
In a retrospective study of patients with duodenal ulcers who received long-term maintenance treatment with ranitidine, 56 patients had non-steroidal anti-inflammatory drug (NSAID)-associated ulcers. Forty-eight of these patients stopped treatment with NSAIDs at the time of presentation. Survival analysis of these 48 patients showed that 97.7% remained free from symptomatic recurrence of ulcer after 5 years of maintenance treatment. Although 52% of the patients with NSAID-associated ulcers presented with haemorrhage, only one patient bled during maintenance treatment, and the cumulative risk of haemorrhage was 2.3% at 5 years. Maintenance treatment with ranitidine appears to be very effective in reducing the risk of symptomatic recurrence and complications of ulcers in patients with NSAID-associated duodenal ulcers.