Histologic Characteristics and Outcome of Familial Non-Polyposis Colorectal Carcinoma

F. Kee Dept. of Epidemiology and Public Health, Dept. of Medicine, and Dept. of Pathology, The Queen's University of Belfast, Belfast, UK

C. C. Patterson Dept. of Epidemiology and Public Health, Dept. of Medicine, and Dept. of Pathology, The Queen's University of Belfast, Belfast, UK

B. J. Collins Dept. of Epidemiology and Public Health, Dept. of Medicine, and Dept. of Pathology, The Queen's University of Belfast, Belfast, UK

S. M. Boyd Dept. of Epidemiology and Public Health, Dept. of Medicine, and Dept. of Pathology, The Queen's University of Belfast, Belfast, UK

J. Sloan Dept. of Epidemiology and Public Health, Dept. of Medicine, and Dept. of Pathology, The Queen's University of Belfast, Belfast, UK

Abstract

Familial cases of non-polyposis colorectal cancer have recently attracted much interest. Little is known about the characteristic histology or natural history of disease in such cases. Our aim was to determine, through a population-based study, whether mucin-secreting tumours were associated with a positive family history and whether ‘familiality’ was an independent prognostic variable. All patients under 55 years of age with histologically verified colorectal cancer in Northern Ireland during 1976–78 were studied. The family history was validated in 95% of all non-polyposis cases (n = 205), and the proband's histologic specimen reviewed in over 99%. Mucin-secreting tumours were significantly associated with a positive family history, but familiality was not found predictive of survival in a multivariate analysis controlling for age, sex, stage, site, symptom duration, differentiation, and histologic type.

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Histologic Characteristics and Outcome of Familial Non-Polyposis Colorectal Carcinoma

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Histologic Characteristics and Outcome of Familial Non-Polyposis Colorectal Carcinoma

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