Gastric Bicarbonate Secretion, Acid Secretion, and Mucosal Blood Flow during Influence of Pentagastrin and Omeprazole in the Cat

K. Guttu Surgical Research Laboratory, Dept. of Surgery, University of Bergen, Bergen, Norway; Dept. of Physiology, University of Gothenburg, Gothenburg, Sweden

B. Røsok Surgical Research Laboratory, Dept. of Surgery, University of Bergen, Bergen, Norway; Dept. of Physiology, University of Gothenburg, Gothenburg, Sweden

H. Gislason Surgical Research Laboratory, Dept. of Surgery, University of Bergen, Bergen, Norway; Dept. of Physiology, University of Gothenburg, Gothenburg, Sweden

L. Fändriks Surgical Research Laboratory, Dept. of Surgery, University of Bergen, Bergen, Norway; Dept. of Physiology, University of Gothenburg, Gothenburg, Sweden

K. Svanes Surgical Research Laboratory, Dept. of Surgery, University of Bergen, Bergen, Norway; Dept. of Physiology, University of Gothenburg, Gothenburg, Sweden

J. E. Grønbech Surgical Research Laboratory, Dept. of Surgery, University of Bergen, Bergen, Norway; Dept. of Physiology, University of Gothenburg, Gothenburg, Sweden

Abstract

In this study secretion of bicarbonate and acid and mucosal blood flow were determined simultaneously in cats. The gastric lumen of anesthetized cats was continuously perfused with isotonic saline. Secretion of HCO₃⁻ and H⁺ was calculated from continuous measurements of pH and Pco₂ in the perfusate. Mucosal blood was measured by means of radiolabeled microspheres. Under resting acid secretory conditions, bicarbonate secretion into the gastric lumen averaged 1.0 μmol/min. Somewhat surprising, both omeprazole (4 mg/kg as bolus) and pentagastrin (16 μg/kg. h intravenously) significantly reduced the HCO₃⁻ secretion. Omeprazole did not influence mucosal blood flow, whereas corpus mucosal blood flow increased during pentagastrin stimulation. Under resting acid secretory conditions and during omeprazole treatment there was a close linear relationship between acid and bicarbonate secretion. No such relationship was found during pentagastrin stimulation of the mucosa. No consistent relationship was obtained between blood flow and bicarbonate secretion in normal gastric mucosa.

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Gastric Bicarbonate Secretion, Acid Secretion, and Mucosal Blood Flow during Influence of Pentagastrin and Omeprazole in the Cat

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Gastric Bicarbonate Secretion, Acid Secretion, and Mucosal Blood Flow during Influence of Pentagastrin and Omeprazole in the Cat

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