Clogging of Biliary Endoprostheses: A Morphologic and Bacteriologic Study

N Dowidar Dept. of Medical and Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark; Dept. of Clinical Microbiology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark; Dept. of Pathology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark

Kolmos Hj Dept. of Medical and Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark; Dept. of Clinical Microbiology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark; Dept. of Pathology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark

H Lyon Dept. of Medical and Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark; Dept. of Clinical Microbiology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark; Dept. of Pathology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark

P. Matzen Dept. of Medical and Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark; Dept. of Clinical Microbiology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark; Dept. of Pathology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark

Abstract

The main problem encountered with the use of biliary endoprostheses is their tendency to clog, which necessitates their exchange. We studied this problem by performing light and electron microscopy and bacterial cultures on both unused and clinically used endoprostheses. These examinations showed several basic defects in their manufacture, such as irregular inner surfaces and badly constructed side holes. The deposit that ultimately led to their occlusion was found mainly to contain bacteria, yeast cells, and plant fibres (food debris) and had a tendency to be concentrated around the side holes. Minimizing the amount of material, bacteria, and plant fibres adhering to the endoprosthesis is the desired goal and may be achieved by improving their manufacture and design.

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Clogging of Biliary Endoprostheses: A Morphologic and Bacteriologic Study

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Clogging of Biliary Endoprostheses: A Morphologic and Bacteriologic Study

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