Monitoring the Effect of Substitution Therapy in Patients with Exocrine Pancreatic Insufficiency

Abstract

Twenty-three outpatients with chronic pancreatitis and severe exocrine insufficiency were studied for the purpose of comparing the effect of Pancrease®, Pankreon®, and Pankreatin® by estimation of duodenal enzyme activity, the faecal fat excretion, and the faecal ¹⁴C-triolein-³H-oleic acid test and, at the same time, to evaluate these tests when monitoring outpatients. The three preparations did not disclose any significant difference in treating steatorrhoea. Pankreatin increased the meal-stimulated duodenal enzyme activity (p < 0.01) and caused reduction in the faecal fat excretion (p < 0.05), whereas no change in these variables were observed with Pankreon or Pancrease. The faecal ¹⁴C-triolein-³H-oleic acid test showed significant improvement in the ¹⁴C-triolein digestion with all three preparations (p < 0.01). The faecal ¹⁴C-triolein-³H-oleic acid test was the most reliable when monitoring outpatients.

Key Words:

• Carbon isotopes
• malabsorption
• pancreatic extracts
• pancreatitis
• chronic
• pancreatitis therapy
• tritium