Radial Analysis of Duodenal Motility Recordings in Humans

Abstract

To analyze radial variations in pressure recordings from the human duodenum, we used a catheter with six radially placed side holes with identical dynamic characteristics. Twenty-one hours of fasting pressure recordings were obtained in six volunteers. Computer-based cross-correlation analysis, event detection and counting, amplitude analysis, and concordance analysis were used for comparing the signals of the individual channels. Both the cross-correlation analysis and the counting of events showed radial asymmetry of contractile activity. This asymmetry was not related to any individual channel. The maximum difference between the individual channels was constantly between diametrically opposite spaced channels. The asymmetry was most pronounced during phase-I-like and phase-II-like activity of the migrating motility complex, whereas a much higher degree of cross-correlation and concordance was shown during phase-III-like activity. The results indicate that a greater in-depth analysis of pressure recordings from the small intestine—such as identification of individual events and differentiation between contractions and artefacts—requires that the recordings as a minimum comprise two diametrically placed side holes at each measurement level.

Key Words:

• Computer analysis
• duodenum
• manometry
• migrating motility complex
• radial analysis