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Original Article

The Effect of Omeprazole-Induced Hypergastrinemia on the Oxyntic Mucosa of Mastomys

, , , &
Pages 667-672 | Received 26 Sep 1990, Accepted 21 Jan 1991, Published online: 08 Jul 2009
 

Abstract

Mastomys is a rodent with a high incidence of spontaneous carcinoids in the acidproducing part of the stomach. The present study was conducted to examine whether hypergastrinemia could promote tumor formation in this species. Mastomys, 4 months of age, were treated for 5 months with omeprazole subcutaneously, 100 μmol/kg body weight daily, and compared with mastomys given the vehicle only. The plasma gastrin concentration and the number of antral gastrin cells were increased in the omeprazole-treated group. The hypergastrinemia was associated with elevated histidine decarboxylase activity and histamine content in the oxyntic mucosa and with a trophic effect on the oxyntic mucosa and the enterochromaffin-like cells. However, no carcinoid tumors were observed, possibly because the strain of mastomys studied does not produce carcinoids spontaneously.

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