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Abstract
Henry DP, Bowsher RR, Verburg KM. Radioenzymatic assay for histamine: development and validation. Scand J Gastroenterol 1991, 26(suppl 180), 26–31
Radioenzymatic assays are sensitive analytic tools that use an enzyme to quantify a substrate for that enzyme. Purified histamine N-methyltransferase has been used as the basis for an assay for histamine. The sensitivity of the procedure is <10fmol. The specificity of the assay is increased when the transferase reaction is carried out at 0–3°C. Data documenting the precision of the assay, the stability of histamine in human plasma, and the gastric secretory rate of histamine are presented along with a chronologic description of the development of the technique.