Gastrin-Histamine Interactions: Direct and Paracrine Elements

C.-N. Chuang Center for Ulcer Research and Education, Medical and Research Services, VA Wadsworth Hospital Center, and the School of Medicine, University of California at Los Angeles, Los Angeles, California, USA

M. C. Y. Chen Center for Ulcer Research and Education, Medical and Research Services, VA Wadsworth Hospital Center, and the School of Medicine, University of California at Los Angeles, Los Angeles, California, USA

A. H. Soll Center for Ulcer Research and Education, Medical and Research Services, VA Wadsworth Hospital Center, and the School of Medicine, University of California at Los Angeles, Los Angeles, California, USA

Abstract

Chuang C-N, Chen MCY, Soll AH. Gastrin-histamine interactions: direct and paracrine elements. Scand J Gastroenterol 1991, 26(suppl 180), 95–103

The receptors mediating the physiologic actions of gastrin on acid secretion and growth have thus far not been localized to specific cells or fully characterized. Studies in canine fundic mucosa indicate that gastrin receptors are present on several cell types, including parietal cells and somatostatin cells. There is also increasing evidence for a gastrin-inducible pool of histamine in the fundic mucosa which is presumably stored in histamine-enterochromaffin-like cells. From the vantage point of studies in the canine fundic mucosa, the issue is no longer which cell type has the gastrin receptor but to sort out the mechanisms by which the effects of the gastrin receptors on endocrine/paracrine (histamine and somatostatin) cells and exocrine (parietal) cells are integrated to regulate secretory function and mucosal growth and differentiation.

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