Session 5: Morphology and Pathogenesis of Endocrine Hyperplasias, Precarcinoid Lesions, and Carcinoids Arising in Chronic Atrophic Gastritis

E. Solcia Dept. of Human Pathology, Ist and IInd Medical Faculty, University of Pavia. and Pathologic Anatomy Service, IRCCS Policlinico San Matteo, Pavia; and Pathologic Anatomy Service and Gastroenterology Division. Varese Multizonal Hospital, Varese, Italy

R. Fiocca Dept. of Human Pathology, Ist and IInd Medical Faculty, University of Pavia. and Pathologic Anatomy Service, IRCCS Policlinico San Matteo, Pavia; and Pathologic Anatomy Service and Gastroenterology Division. Varese Multizonal Hospital, Varese, Italy

L. Villani Dept. of Human Pathology, Ist and IInd Medical Faculty, University of Pavia. and Pathologic Anatomy Service, IRCCS Policlinico San Matteo, Pavia; and Pathologic Anatomy Service and Gastroenterology Division. Varese Multizonal Hospital, Varese, Italy

A. Gianatti Dept. of Human Pathology, Ist and IInd Medical Faculty, University of Pavia. and Pathologic Anatomy Service, IRCCS Policlinico San Matteo, Pavia; and Pathologic Anatomy Service and Gastroenterology Division. Varese Multizonal Hospital, Varese, Italy

M. Cornaggia Dept. of Human Pathology, Ist and IInd Medical Faculty, University of Pavia. and Pathologic Anatomy Service, IRCCS Policlinico San Matteo, Pavia; and Pathologic Anatomy Service and Gastroenterology Division. Varese Multizonal Hospital, Varese, Italy

A. Chiaravalli Dept. of Human Pathology, Ist and IInd Medical Faculty, University of Pavia. and Pathologic Anatomy Service, IRCCS Policlinico San Matteo, Pavia; and Pathologic Anatomy Service and Gastroenterology Division. Varese Multizonal Hospital, Varese, Italy

M. Curzio Dept. of Human Pathology, Ist and IInd Medical Faculty, University of Pavia. and Pathologic Anatomy Service, IRCCS Policlinico San Matteo, Pavia; and Pathologic Anatomy Service and Gastroenterology Division. Varese Multizonal Hospital, Varese, Italy

C. Capella Dept. of Human Pathology, Ist and IInd Medical Faculty, University of Pavia. and Pathologic Anatomy Service, IRCCS Policlinico San Matteo, Pavia; and Pathologic Anatomy Service and Gastroenterology Division. Varese Multizonal Hospital, Varese, Italy

show all

Abstract

Solcia E, Fiocca R, Villani L, Gianatti A, Cornaggia M, Chiaravalli A, Curzio M, Capella C. Morphology and pathogenesis of endocrine hyperplasias, precarcinoid lesions, and carcinoids arising in chronic atrophic gastritis. Scand J Gastroenterol 1991, 26(suppl 180), 146–159

The spectrum of endocrine cell changes occurring in 80 cases of body-fundus chronic atrophic gastritis (CAG), mostly type A or multifocal, including various types of hyperplasia, precarcinoid lesions (20 cases), and neoplasia (carcinoid, 24 cases) have been analyzed histologically, histochemically, and ultrastructurally. Changes associated with gland atrophy, pyloric- or intestinal-type metaplasia, regenerative hyperplasia, and hypergastrinemia have been identified and their neoplastic potential evaluated in the light of their proliferative capacity (bromodeoxyuridine incorporation) and clinicopathologic behavior. A close link between disseminated precarcinoid lesions of non-tumor mucosa and multiple carcinoids (carcinoidosis) arising in hypergastrinemic type-A CAG is suggested. Hyperplastic changes. including endocrine cell clusters. seem to have no or only minimal neoplastic potential.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Session 5: Morphology and Pathogenesis of Endocrine Hyperplasias, Precarcinoid Lesions, and Carcinoids Arising in Chronic Atrophic Gastritis

Information for

Open access

Opportunities

Help and information

Session 5: Morphology and Pathogenesis of Endocrine Hyperplasias, Precarcinoid Lesions, and Carcinoids Arising in Chronic Atrophic Gastritis

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature