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Original Article

Fecal Immunoreactive Lipase: A New Tubeless Pancreatic Function Test

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Pages 289-294 | Received 06 Mar 1991, Accepted 16 Nov 1991, Published online: 08 Jul 2009
 

Abstract

Immunoreactive lipase (IRL) was measured in 368 stool samples from 231 individuals by means of a new enzyme-linked immunoabsorbant assay technic, to test its validity as an indicator of exocrine pancreatic insufficiency. Ninety-seven stool samples from 64 healthy volunteers showed a logarithmically normal distribution of IRL values and a median IRL concentration of 17 μg/g (range, 2.75-117.3 μg/g) with a statistically calculated lower normal limit of 4 μg/g. In 100 stool samples from patients with chronic pancreatitis and proven steatorrhea the median IRL concentration of 6 μg/g (range, 0.002-107 μg/g) was significantly lower than that of normal controls and of 52 stool samples from patients with chronic pancreatitis without steatorrhea (IRL, 40 μg/g; range, 0.55-302 μg/g), 45 stool samples from 23 patients with celiac disease (IRL, 96 μg/g; range, 6.05-563 μg/g), and 30 stool samples from 26 patients with chronic diarrhea (IRL, 57 μg/g; range, 4.2-573 μg/g). It is concluded that fecal IRL is a promising new enzyme test with low diagnostic sensitivity (34%) but excellent diagnostic specificity (98%) in chronic pancreatitis and for diagnostic study of chronic diarrheal disorders. In contrast to fecal chymotrypsin, the test results are unaffected by pancreatic enzyme replacement therapy.

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