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Original Article

Bismuth Absorption from 205Bi-Labelled Pharmaceutical Bismuth Compounds Used in the Treatment of Peptic Ulcer Disease

, , , &
Pages 333-336 | Received 11 Jun 1991, Accepted 25 Nov 1991, Published online: 08 Jul 2009
 

Abstract

The absorption of bismuth from five 205Bi-labelled pharmaceutically used bismuth compounds was studied in man. From single oral doses of all compounds under investigation only <0.1% bismuth was absorbed and excreted with the urine. A significantly higher absorption was observed from the colloidal bismuth subcitrate (0.042% of the dose) and the basic bismuth gallate (0.038%) than from the basic bismuth salicylate, nitrate, and aluminate (0.005-0.002%). No retention of bismuth in the whole body was found from the single dose experiment. The biologic fast-term half-lives of absorbed bismuth were calculated to be 0.12 and 1.5 days.

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