Islet Amyloid Polypeptide-Producing Pancreatic Islet Cell Tumor a Clinical and Biochemical Characterization

M. Stridsberg Dept. of Clinical Chemistry, Dept. of Pathology, and Dept. of Internal Medicine, Ludwig Institute for Cancer Research, and Dept. of Internal Medicine, University Hospital, Uppsala, Sweden

E. Wilander Dept. of Clinical Chemistry, Dept. of Pathology, and Dept. of Internal Medicine, Ludwig Institute for Cancer Research, and Dept. of Internal Medicine, University Hospital, Uppsala, Sweden

K. ØUberg Dept. of Clinical Chemistry, Dept. of Pathology, and Dept. of Internal Medicine, Ludwig Institute for Cancer Research, and Dept. of Internal Medicine, University Hospital, Uppsala, Sweden

G. Lundqvist Dept. of Clinical Chemistry, Dept. of Pathology, and Dept. of Internal Medicine, Ludwig Institute for Cancer Research, and Dept. of Internal Medicine, University Hospital, Uppsala, Sweden

B. Eriksson Dept. of Clinical Chemistry, Dept. of Pathology, and Dept. of Internal Medicine, Ludwig Institute for Cancer Research, and Dept. of Internal Medicine, University Hospital, Uppsala, Sweden

Abstract

Islet amyloid peptide (IAPP) or amylin is a recently discovered polypeptide without settled physiology in man. We present a patient with an endocrine pancreatic tumor secreting huge amounts of IAPP-like immunoreactivity (20,000 mol/l) and a concomitant development of diabetes mellitus. The release of insulin and pancreatic polypeptide (PP) was totally absent after an oral glucose load and a mixed meal, respectively. Tumor secretion of IAPP-like immunoreactivity seemed to be influenced by cholinergic mechanisms and by nutrients. The observed effects on insulin and PP secretion by high circulating levels of IAPP-like immunoreactivity may be of beneficial value for further studies of the physiology of IAPP in man.

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Islet Amyloid Polypeptide-Producing Pancreatic Islet Cell Tumor a Clinical and Biochemical Characterization

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Islet Amyloid Polypeptide-Producing Pancreatic Islet Cell Tumor a Clinical and Biochemical Characterization

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