Effect of Platelet-Derived Growth Factor-BB on Indomethacin-Induced Gastric Lesions in Rats

A. Guglietta Gastrointestinal Disorders Group, Dept. of Experimental Therapy Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan and Glaxo Research Laboratories, Research Triangle Park, North Carolina, USA

T. Hervada Gastrointestinal Disorders Group, Dept. of Experimental Therapy Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan and Glaxo Research Laboratories, Research Triangle Park, North Carolina, USA

R. V. Nardi Gastrointestinal Disorders Group, Dept. of Experimental Therapy Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan and Glaxo Research Laboratories, Research Triangle Park, North Carolina, USA

C. A. Lesch Gastrointestinal Disorders Group, Dept. of Experimental Therapy Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan and Glaxo Research Laboratories, Research Triangle Park, North Carolina, USA

Abstract

The effect of platelet-derived growth factor-BB (PDGF-BB) was evaluated in rats with indomethacin-induced gastric lesions. Animals were treated with either saline solution or several doses of PDGF-BB given orally. Rats treated with 0.1 nmol/kg PDGF-BB showed a statistically significant reduction of gastric damage. Higher doses did not produce any further reduction of gastric damage, and a return toward control values was observed. The effect on lesions was independent of inhibition of gastric acid secretion, since a dose of 0.1 nmol/kg of this growth factor failed to modify gastric acid secretion stimulated by pylorus ligation

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Effect of Platelet-Derived Growth Factor-BB on Indomethacin-Induced Gastric Lesions in Rats

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Effect of Platelet-Derived Growth Factor-BB on Indomethacin-Induced Gastric Lesions in Rats

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