Modern Approach to Alcoholic Liver Disease

Abstract

The pathogenesis of alcoholic liver disease is unclear. The recent literature on pathogenic factors, including direct effects of ethanol and its proximate metabolite acetaldehyde, associated nutritional factors, the formation of acetaldehyde-protein adducts, associated immune alterations, and the potential for liver injury due to coexisting hepatitis virus infection, is highlighted. The therapy of patients with advanced alcoholic liver injury, especially alcoholic hepatitis, is also controversial. It seems reasonable that all patients should receive adequate nutrition even if parenteral or enteral supplementation is required. Corticosteroid administration may benefit those patients with alcoholic hepatitis who have coexisting spontaneous hepatic encephalopathy and no gastrointestinal bleeding. For patients with complications from end-stage alcoholic cirrhosis, liver transplantation should be considered, as the patient with alcoholic cirrhosis does as well after liver transplantation as those patients with other forms of end-stage liver disease.

Key Words:

• Acetaldehyde
• acetaldehyde dehydrogenase
• acetaldehyde-protein adducts
• alcohol dehydrogenase
• cirrhosis
• alcoholic
• ethanol
• hepatitis
• alcoholic
• immune mechanisms
• liver disease
• alcoholic
• liver transplantation