Burn-Induced Gastric Mucosal Hemodynamic Disturbance in the Rat: Role of Platelet-Activating Factor

T. Binnaka Third Dept. of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan

T. Yamaguchi Third Dept. of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan

Y. Kubota Third Dept. of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan

K. Fujimura Third Dept. of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan

K. Tani Third Dept. of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan

S. Kitagawa Third Dept. of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan

T. Mizuno Third Dept. of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan

K. Inoue Third Dept. of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan

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Abstract

The role of platelet-activating factor (PAF) as a mediator of gastric damage associated with burn injury was examined in the rat. Gastric mucosal hemodynamics was recorded continuously by means of laser-Doppler flowmetry and reflectance spectrophotometry. Burn injury induced prolonged hypotension and rapid-onset and long-lasting gastric mucosal hemodynamic derangement—that is, ischemia with congestion. This hemodynamic disturbance was significantly inhibited by CV-6209, a specific PAF antagonist. Elevated tissue levels of thiobarbituric acid reactants and pathologic changes in the gastric mucosa subsequent to burn injury were also significantly alleviated by the preadministration of CV-6209. These results strongly suggest a role of PAF as an important mediator of gastric damage after burn injury through its potent vasoactive effect on gastric microcirculation.

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Burn-Induced Gastric Mucosal Hemodynamic Disturbance in the Rat: Role of Platelet-Activating Factor

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