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Scandinavian Journal of Gastroenterology Volume 27, 1992 - Issue 2
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Original Article

Enzyme Substitution in Pancreatic Disease: Is Colipase Activity Sufficient?

C. Erlanson-Albertsson Dept. of Medical and Physiological Chemistry, University of Lund, Lund, Sweden; Gastrointestinal Unit, Dept. of Medicine, Karolinska Hospital, Stockholm, Sweden
&
O. Wisén Dept. of Medical and Physiological Chemistry, University of Lund, Lund, Sweden; Gastrointestinal Unit, Dept. of Medicine, Karolinska Hospital, Stockholm, Sweden
Pages 108-110 | Received 28 May 1990, Accepted 29 Aug 1991, Published online: 05 Aug 2009
 
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Abstract

The aim of the present study was to determine colipase activity in various pancreatic enzyme tablets to ascertain whether these contained sufficient amounts of colipase to activate lipase during fat digestion. Colipase activity in all preparations tested exceeded that of lipase activity by a factor of 1.4–1.9 on a molar activity basis. Since optimal activity of lipase is obtained with colipase being present in a colipase to lipase molar activity ratio of 1.0, it is concluded that these preparations contain a sufficient amount of colipase to activate lipase.

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