Lansoprazole versus Omeprazole in Short-Term Treatment of Reflux Oesophagitis Results of a Scandinavian Multicentre Trial

J. G. Hatlebakk Division of Gastroenterology, Dept. of Medicine, Haukeland University Hospital, Bergen; Dept. of Medicine, Rogaland Regional Hospital, Stavanger; Dept. of Medicine, Vest-Agder Central Hospital, Kristiansand; Dept. of Medicine, The Deaconess Hospital, Bergen; Dept. of Medicine, Møre og Romsdal Central Hospital, Ålesund; Dept. of Medicine, Vestfold Central Hospital, Tønsberg; Dept. of Medicine, Molde Hospital, Molde, Norway; Dept. of Medicine, Bollnäs Hospital, Bollnäs, Sandviken, Sweden; Depts. of Medicine and Surgery, Sandviken Hospital, Sandviken, Sweden

A. Berstad Division of Gastroenterology, Dept. of Medicine, Haukeland University Hospital, Bergen; Dept. of Medicine, Rogaland Regional Hospital, Stavanger; Dept. of Medicine, Vest-Agder Central Hospital, Kristiansand; Dept. of Medicine, The Deaconess Hospital, Bergen; Dept. of Medicine, Møre og Romsdal Central Hospital, Ålesund; Dept. of Medicine, Vestfold Central Hospital, Tønsberg; Dept. of Medicine, Molde Hospital, Molde, Norway; Dept. of Medicine, Bollnäs Hospital, Bollnäs, Sandviken, Sweden; Depts. of Medicine and Surgery, Sandviken Hospital, Sandviken, Sweden

L. Carling Division of Gastroenterology, Dept. of Medicine, Haukeland University Hospital, Bergen; Dept. of Medicine, Rogaland Regional Hospital, Stavanger; Dept. of Medicine, Vest-Agder Central Hospital, Kristiansand; Dept. of Medicine, The Deaconess Hospital, Bergen; Dept. of Medicine, Møre og Romsdal Central Hospital, Ålesund; Dept. of Medicine, Vestfold Central Hospital, Tønsberg; Dept. of Medicine, Molde Hospital, Molde, Norway; Dept. of Medicine, Bollnäs Hospital, Bollnäs, Sandviken, Sweden; Depts. of Medicine and Surgery, Sandviken Hospital, Sandviken, Sweden

L. E. Svedberg Division of Gastroenterology, Dept. of Medicine, Haukeland University Hospital, Bergen; Dept. of Medicine, Rogaland Regional Hospital, Stavanger; Dept. of Medicine, Vest-Agder Central Hospital, Kristiansand; Dept. of Medicine, The Deaconess Hospital, Bergen; Dept. of Medicine, Møre og Romsdal Central Hospital, Ålesund; Dept. of Medicine, Vestfold Central Hospital, Tønsberg; Dept. of Medicine, Molde Hospital, Molde, Norway; Dept. of Medicine, Bollnäs Hospital, Bollnäs, Sandviken, Sweden; Depts. of Medicine and Surgery, Sandviken Hospital, Sandviken, Sweden

P. Unge Division of Gastroenterology, Dept. of Medicine, Haukeland University Hospital, Bergen; Dept. of Medicine, Rogaland Regional Hospital, Stavanger; Dept. of Medicine, Vest-Agder Central Hospital, Kristiansand; Dept. of Medicine, The Deaconess Hospital, Bergen; Dept. of Medicine, Møre og Romsdal Central Hospital, Ålesund; Dept. of Medicine, Vestfold Central Hospital, Tønsberg; Dept. of Medicine, Molde Hospital, Molde, Norway; Dept. of Medicine, Bollnäs Hospital, Bollnäs, Sandviken, Sweden; Depts. of Medicine and Surgery, Sandviken Hospital, Sandviken, Sweden

P. Ekström Division of Gastroenterology, Dept. of Medicine, Haukeland University Hospital, Bergen; Dept. of Medicine, Rogaland Regional Hospital, Stavanger; Dept. of Medicine, Vest-Agder Central Hospital, Kristiansand; Dept. of Medicine, The Deaconess Hospital, Bergen; Dept. of Medicine, Møre og Romsdal Central Hospital, Ålesund; Dept. of Medicine, Vestfold Central Hospital, Tønsberg; Dept. of Medicine, Molde Hospital, Molde, Norway; Dept. of Medicine, Bollnäs Hospital, Bollnäs, Sandviken, Sweden; Depts. of Medicine and Surgery, Sandviken Hospital, Sandviken, Sweden

L. Halvorsen Division of Gastroenterology, Dept. of Medicine, Haukeland University Hospital, Bergen; Dept. of Medicine, Rogaland Regional Hospital, Stavanger; Dept. of Medicine, Vest-Agder Central Hospital, Kristiansand; Dept. of Medicine, The Deaconess Hospital, Bergen; Dept. of Medicine, Møre og Romsdal Central Hospital, Ålesund; Dept. of Medicine, Vestfold Central Hospital, Tønsberg; Dept. of Medicine, Molde Hospital, Molde, Norway; Dept. of Medicine, Bollnäs Hospital, Bollnäs, Sandviken, Sweden; Depts. of Medicine and Surgery, Sandviken Hospital, Sandviken, Sweden

A. Stallemo Division of Gastroenterology, Dept. of Medicine, Haukeland University Hospital, Bergen; Dept. of Medicine, Rogaland Regional Hospital, Stavanger; Dept. of Medicine, Vest-Agder Central Hospital, Kristiansand; Dept. of Medicine, The Deaconess Hospital, Bergen; Dept. of Medicine, Møre og Romsdal Central Hospital, Ålesund; Dept. of Medicine, Vestfold Central Hospital, Tønsberg; Dept. of Medicine, Molde Hospital, Molde, Norway; Dept. of Medicine, Bollnäs Hospital, Bollnäs, Sandviken, Sweden; Depts. of Medicine and Surgery, Sandviken Hospital, Sandviken, Sweden

N. Hovdenak Division of Gastroenterology, Dept. of Medicine, Haukeland University Hospital, Bergen; Dept. of Medicine, Rogaland Regional Hospital, Stavanger; Dept. of Medicine, Vest-Agder Central Hospital, Kristiansand; Dept. of Medicine, The Deaconess Hospital, Bergen; Dept. of Medicine, Møre og Romsdal Central Hospital, Ålesund; Dept. of Medicine, Vestfold Central Hospital, Tønsberg; Dept. of Medicine, Molde Hospital, Molde, Norway; Dept. of Medicine, Bollnäs Hospital, Bollnäs, Sandviken, Sweden; Depts. of Medicine and Surgery, Sandviken Hospital, Sandviken, Sweden

R. Trondstad Division of Gastroenterology, Dept. of Medicine, Haukeland University Hospital, Bergen; Dept. of Medicine, Rogaland Regional Hospital, Stavanger; Dept. of Medicine, Vest-Agder Central Hospital, Kristiansand; Dept. of Medicine, The Deaconess Hospital, Bergen; Dept. of Medicine, Møre og Romsdal Central Hospital, Ålesund; Dept. of Medicine, Vestfold Central Hospital, Tønsberg; Dept. of Medicine, Molde Hospital, Molde, Norway; Dept. of Medicine, Bollnäs Hospital, Bollnäs, Sandviken, Sweden; Depts. of Medicine and Surgery, Sandviken Hospital, Sandviken, Sweden

E. Kittang Division of Gastroenterology, Dept. of Medicine, Haukeland University Hospital, Bergen; Dept. of Medicine, Rogaland Regional Hospital, Stavanger; Dept. of Medicine, Vest-Agder Central Hospital, Kristiansand; Dept. of Medicine, The Deaconess Hospital, Bergen; Dept. of Medicine, Møre og Romsdal Central Hospital, Ålesund; Dept. of Medicine, Vestfold Central Hospital, Tønsberg; Dept. of Medicine, Molde Hospital, Molde, Norway; Dept. of Medicine, Bollnäs Hospital, Bollnäs, Sandviken, Sweden; Depts. of Medicine and Surgery, Sandviken Hospital, Sandviken, Sweden

O. J. Lange Division of Gastroenterology, Dept. of Medicine, Haukeland University Hospital, Bergen; Dept. of Medicine, Rogaland Regional Hospital, Stavanger; Dept. of Medicine, Vest-Agder Central Hospital, Kristiansand; Dept. of Medicine, The Deaconess Hospital, Bergen; Dept. of Medicine, Møre og Romsdal Central Hospital, Ålesund; Dept. of Medicine, Vestfold Central Hospital, Tønsberg; Dept. of Medicine, Molde Hospital, Molde, Norway; Dept. of Medicine, Bollnäs Hospital, Bollnäs, Sandviken, Sweden; Depts. of Medicine and Surgery, Sandviken Hospital, Sandviken, Sweden

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Abstract

To evaluate the therapeutic potential of the newly developed proton pump inhibitor lansoprazole in patients with reflux oesophagitis, we performed a double-blind randomized clinical trial comparing 20 mg omeprazole and 30 mg lansoprazole, involving 229 patients at 9 Scandinavian hospitals. The treatment period was 4 or 8 weeks, and main efficacy variables were healing of endoscopic changes, relief of reflux symptoms, and occurrence of adverse events. No significant difference in terms of healing was found, either after 4 or after 8 weeks' treatment. Patients receiving lansoprazole experienced a greater improvement in heartburn after 4 weeks (p = 0.03), and there was a similar trend for acid regurgitation. Lansoprazole was found to be an effective and safe alternative to omeprazole in short-term treatment of moderate reflux oesophagitis.

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Lansoprazole versus Omeprazole in Short-Term Treatment of Reflux Oesophagitis Results of a Scandinavian Multicentre Trial

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Lansoprazole versus Omeprazole in Short-Term Treatment of Reflux Oesophagitis Results of a Scandinavian Multicentre Trial

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