Parietal Cell Antibodies among Peruvians with Gastric Pathologic Changes

I. C. Kohlstadt The Johns Hopkins University, Baltimore, Maryland, USA; Universidad Peruana Cayetano Heredia, Lima, Peru

E. A. Antunez de Mayolo The Johns Hopkins University, Baltimore, Maryland, USA; Universidad Peruana Cayetano Heredia, Lima, Peru

R. H. Gilman The Johns Hopkins University, Baltimore, Maryland, USA; Universidad Peruana Cayetano Heredia, Lima, Peru

R. Leon-Barua The Johns Hopkins University, Baltimore, Maryland, USA; Universidad Peruana Cayetano Heredia, Lima, Peru

A. Ramirez-Ramos The Johns Hopkins University, Baltimore, Maryland, USA; Universidad Peruana Cayetano Heredia, Lima, Peru

C. Rodriguez The Johns Hopkins University, Baltimore, Maryland, USA; Universidad Peruana Cayetano Heredia, Lima, Peru

S. Recavarren The Johns Hopkins University, Baltimore, Maryland, USA; Universidad Peruana Cayetano Heredia, Lima, Peru

W. Spira The Johns Hopkins University, Baltimore, Maryland, USA; Universidad Peruana Cayetano Heredia, Lima, Peru

J. Watanabe The Johns Hopkins University, Baltimore, Maryland, USA; Universidad Peruana Cayetano Heredia, Lima, Peru

R. Berenson The Johns Hopkins University, Baltimore, Maryland, USA; Universidad Peruana Cayetano Heredia, Lima, Peru

C. Guevara The Johns Hopkins University, Baltimore, Maryland, USA; Universidad Peruana Cayetano Heredia, Lima, Peru

J. Palomino The Johns Hopkins University, Baltimore, Maryland, USA; Universidad Peruana Cayetano Heredia, Lima, Peru

M. Alvarez The Johns Hopkins University, Baltimore, Maryland, USA; Universidad Peruana Cayetano Heredia, Lima, Peru

J. Cok The Johns Hopkins University, Baltimore, Maryland, USA; Universidad Peruana Cayetano Heredia, Lima, Peru

C. Ramirez-Icaza The Johns Hopkins University, Baltimore, Maryland, USA; Universidad Peruana Cayetano Heredia, Lima, Peru

show all

Abstract

Parietal cell antibodies were present in 12% of 272 Peruvians presenting for endoscopy. Gender, age, socioeconomic status, ethnic background (Peruvian versus Japanese), and altitude at which the patient lived were not associated with the presence of parietal cell antibodies. No significant relationship could be shown between the presence of parietal cell antibodies and either Helicobacter pylori infection or gastric lesions, including chronic atrophic gastritis. Loss of proper gastric glands was significantly more common in patients who had H. pylori infection than in those in whom no H, pylori was found on biopsy (78 of 114 (85%) versus 14 of 36 (39%); p = 0.002). Our data suggest that, although parietal cell antibodies are present in third-world populations, they are unrelated to H. pylori infection and that pathologic changes associated with this infection are not mediated by the action of parietal cell antibodies on the cells of the stomach.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Parietal Cell Antibodies among Peruvians with Gastric Pathologic Changes

Information for

Open access

Opportunities

Help and information

Parietal Cell Antibodies among Peruvians with Gastric Pathologic Changes

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature