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Original Article

Potential of Measurements of Unsaturated Vitamin B12-Binding Capacity in Serial Colonoscopic Biopsy Specimens for Global and Regional Assessments of Disease Severity in Inflammatory Bowel Disease

, , , &
Pages 1005-1010 | Received 19 Feb 1993, Accepted 14 May 1993, Published online: 08 Jul 2009
 

Abstract

We investigated whether measurements of unsaturated vitamin B|2-binding capacity (UBBC), in homo-genates of serial colonoscopic biopsy specimens, could be used as objective measures of disease severity in ulcerative colitis (UC) and Crohn's disease (CD). On a regional basis UBBC activity correlated with and showed good agreement with endoscopic and histologic activity scores (r = 0.8 and 0.6, respectively, for UC, and r = 0.7 and 0.7, respectively, for CD). For global assessment aggregate UBBC, endoscopic and histologic scores were compared with standard clinical activity scores. In UC, correlations with the van Hees index were r = 0.7, 0.8, and 0.7, respectively, and UBBC assays accurately reflected both regional and global disease activity. In CD, correlations with the CDAI were -0.1, 0.7, and 0.6, respectively. Thus, aggregate UBBC scores failed to reflect disease activity in CD, in which focal deep ulcers may produce high symptom scores but in which adjacent specimens may show no accute inflammation.

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