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Scandinavian Journal of Gastroenterology Volume 28, 1993 - Issue 10
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Original Article

Effect of Helicobacter pylori Eradication on Antral Gastrin- and Somatostatin-Immunoreactive Cell Density and Gastrin and Somatostatin Concentrations

D. M. M. Queiroz Laboratory of Research in Bacteriology and Depts. of Pathology and Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minais Gerais, Brazil
,
E. N. Mendes Laboratory of Research in Bacteriology and Depts. of Pathology and Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minais Gerais, Brazil
,
G. A. Rocha Laboratory of Research in Bacteriology and Depts. of Pathology and Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minais Gerais, Brazil
,
S. B. Moura Laboratory of Research in Bacteriology and Depts. of Pathology and Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minais Gerais, Brazil
,
L. M. H. Resende Laboratory of Research in Bacteriology and Depts. of Pathology and Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minais Gerais, Brazil
,
A. J. A. Barbosa Laboratory of Research in Bacteriology and Depts. of Pathology and Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minais Gerais, Brazil
,
L. G. V. Coelho Laboratory of Research in Bacteriology and Depts. of Pathology and Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minais Gerais, Brazil
,
M. C. E. Passos Laboratory of Research in Bacteriology and Depts. of Pathology and Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minais Gerais, Brazil
,
L. P. Castro Laboratory of Research in Bacteriology and Depts. of Pathology and Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minais Gerais, Brazil
,
C. A. Oliveira Laboratory of Research in Bacteriology and Depts. of Pathology and Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minais Gerais, Brazil
&
G. F. Lima Laboratory of Research in Bacteriology and Depts. of Pathology and Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minais Gerais, Brazil
 show all
Pages 858-864 | Received 01 Feb 1993, Accepted 14 Apr 1993, Published online: 08 Jul 2009
 
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Abstract

The density of antral gastrin (G)- and somatostatin (D)-immunoreactive cells and the contents of antral gastrin and somatostatin were investigated in endoscopic antral biopsy specimens from patients with duodenal ulcer before and after eradication of Helicobacter pylori. After H. pylori eradication both antral somatostatin concentration (p = 0.0002) and antral D-cell density (p = 0.01) increased significantly. Conversely, although the number of G-cells was unchanged, antral (p = 0.0002) and serum (p = 0.001) gastrin contents decreased significantly. The number of oxyntic D-cells did not change significantly. These results strongly suggest that the hypergastrinaemia observed in H. pylori-positive patients may be due to a deficiency in antral somatostatin, which normally inhibits the synthesis and release of gastrin.

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Related Research Data

Gastrin, G-, D-cells in children gastritis
Source: Wiley
The Family Helicobacteraceae
Source: Springer Berlin Heidelberg

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