Rectal Epithelial γ/δ T-Lymphocyte Responses to Local Gluten Challenge in Coeliac Disease

Abstract

Sturgess RP, Loft D, Kontakou M, Crowe P, Marsh MN, Ciclitira PJ. Rectal epithelial γ/δ T-lymphocyte responses to local gluten challenge in coeliac disease. Scand J Gastroenterol 1993;28:760-762.

The proportion of intra-epithelial lymphocytes (IEL) that utilize the γ/δ form of the T-cell receptor (TCR) is increased in coeliac disease, but their function remains unexplained. The response of intraepithelial lymphocytes to rectal gluten challenge in coeliac and control subjects was studied after a rectal challenge of 2 g of Frazer's fraction III. A marked rise in CD3+ IEL occurred after challenge in the coeliac patients, peaking at 6 h and returning to normal by 48 h, with no significant changes in the γ/δ TCR+ IEL. The IEL did not significantly change after gluten challenge in the controls. Acute gluten challenge induces infiltration of the rectal mucosa by T cells in coeliac patients, which is not accompanied acutely by increased numbers of γ/δ TCR+ IEL. This study supports the hypothesis that α/β TCR+ T cells may be of importance in the early response of coeliac patients to local gluten challenge.

Key Words:

• Coeliac disease
• T-cell receptor
• γ/δ T-cell receptor
• rectum